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Fusion gene ID: 31622 |
FusionGeneSummary for RNH1_HRAS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNH1_HRAS | Fusion gene ID: 31622 | Hgene | Tgene | Gene symbol | RNH1 | HRAS | Gene ID | 246243 | 3265 |
| Gene name | ribonuclease H1 | HRas proto-oncogene, GTPase | |
| Synonyms | H1RNA|PEOB2|RNH1 | C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras | |
| Cytomap | 2p25.3 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribonuclease H1ribonuclease H type II | GTPase HRasGTP- and GDP-binding peptide BHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncogene homologHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinc-ras-Ki-2 activated oncogenep19 H-RasIDX | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P13489 | P01112 | |
| Ensembl transtripts involved in fusion gene | ENST00000534797, ENST00000397614, ENST00000397615, ENST00000397604, ENST00000533410, ENST00000438658, ENST00000354420, ENST00000356187, ENST00000533592, | ENST00000397594, ENST00000397596, ENST00000451590, ENST00000417302, ENST00000311189, ENST00000468682, | |
| Fusion gene scores | * DoF score | 6 X 2 X 5=60 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/60*10)=0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RNH1 [Title/Abstract] AND HRAS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HRAS | GO:0001934 | positive regulation of protein phosphorylation | 22065586 |
| Tgene | HRAS | GO:0007050 | cell cycle arrest | 9054499 |
| Tgene | HRAS | GO:0007093 | mitotic cell cycle checkpoint | 9054499 |
| Tgene | HRAS | GO:0007265 | Ras protein signal transduction | 23027131 |
| Tgene | HRAS | GO:0008284 | positive regulation of cell proliferation | 9765203 |
| Tgene | HRAS | GO:0008285 | negative regulation of cell proliferation | 9054499 |
| Tgene | HRAS | GO:0010629 | negative regulation of gene expression | 23027131 |
| Tgene | HRAS | GO:0010863 | positive regulation of phospholipase C activity | 11022048 |
| Tgene | HRAS | GO:0030335 | positive regulation of cell migration | 23027131 |
| Tgene | HRAS | GO:0034260 | negative regulation of GTPase activity | 23027131 |
| Tgene | HRAS | GO:0043406 | positive regulation of MAP kinase activity | 23027131 |
| Tgene | HRAS | GO:0043410 | positive regulation of MAPK cascade | 9765203 |
| Tgene | HRAS | GO:0043547 | positive regulation of GTPase activity | 23027131 |
| Tgene | HRAS | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22065586|23027131 |
| Tgene | HRAS | GO:0046330 | positive regulation of JNK cascade | 22065586 |
| Tgene | HRAS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| Tgene | HRAS | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Tgene | HRAS | GO:0090303 | positive regulation of wound healing | 23027131 |
| Tgene | HRAS | GO:0090398 | cellular senescence | 9054499 |
| Tgene | HRAS | GO:1900029 | positive regulation of ruffle assembly | 23027131 |
| Tgene | HRAS | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 23027131 |
| Tgene | HRAS | GO:2000630 | positive regulation of miRNA metabolic process | 23027131 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CR-7382-01A | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000534797 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000534797 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000534797 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000534797 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000534797 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-5UTR | ENST00000534797 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397614 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397614 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397614 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397614 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397614 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-5UTR | ENST00000397614 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397615 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397615 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397615 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397615 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000397615 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-5UTR | ENST00000397615 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000397604 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000397604 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000397604 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000397604 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000397604 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-5UTR | ENST00000397604 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000533410 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000533410 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000533410 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000533410 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000533410 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-5UTR | ENST00000533410 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000438658 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000438658 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000438658 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000438658 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000438658 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-5UTR | ENST00000438658 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000354420 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000354420 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000354420 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000354420 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000354420 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-5UTR | ENST00000354420 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000356187 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000356187 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000356187 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000356187 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-3CDS | ENST00000356187 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| 5UTR-5UTR | ENST00000356187 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000533592 | ENST00000397594 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000533592 | ENST00000397596 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000533592 | ENST00000451590 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000533592 | ENST00000417302 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-3CDS | ENST00000533592 | ENST00000311189 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
| intron-5UTR | ENST00000533592 | ENST00000468682 | RNH1 | chr11 | 507113 | - | HRAS | chr11 | 533944 | - |
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FusionProtFeatures for RNH1_HRAS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNH1 | HRAS |