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Fusion gene ID: 31551 |
FusionGeneSummary for RNF217_MRPS27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF217_MRPS27 | Fusion gene ID: 31551 | Hgene | Tgene | Gene symbol | RNF217 | MRPS27 | Gene ID | 154214 | 23107 |
| Gene name | ring finger protein 217 | mitochondrial ribosomal protein S27 | |
| Synonyms | C6orf172|IBRDC1|OSTL|dJ84N20.1 | MRP-S27|S27mt | |
| Cytomap | 6q22.31 | 5q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable E3 ubiquitin-protein ligase RNF217IBR domain containing 1opposite STL | 28S ribosomal protein S27, mitochondrialmitochondrial 28S ribosomal protein S27mitochondrial small ribosomal subunit protein mS27 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8TC41 | Q92552 | |
| Ensembl transtripts involved in fusion gene | ENST00000521654, ENST00000560949, ENST00000454842, ENST00000368414, ENST00000359704, ENST00000275184, | ENST00000261413, ENST00000457646, ENST00000513900, ENST00000515404, ENST00000522562, ENST00000522095, | |
| Fusion gene scores | * DoF score | 7 X 4 X 7=196 | 3 X 3 X 2=18 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/196*10)=-0.970853654340483 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RNF217 [Title/Abstract] AND MRPS27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB085590 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - | ||
| ChiTaRS3.1 | AK310474 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000521654 | ENST00000261413 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000521654 | ENST00000457646 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000521654 | ENST00000513900 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000521654 | ENST00000515404 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000521654 | ENST00000522562 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-intron | ENST00000521654 | ENST00000522095 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000560949 | ENST00000261413 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000560949 | ENST00000457646 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000560949 | ENST00000513900 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000560949 | ENST00000515404 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000560949 | ENST00000522562 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-intron | ENST00000560949 | ENST00000522095 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000454842 | ENST00000261413 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000454842 | ENST00000457646 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000454842 | ENST00000513900 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000454842 | ENST00000515404 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000454842 | ENST00000522562 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-intron | ENST00000454842 | ENST00000522095 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000368414 | ENST00000261413 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000368414 | ENST00000457646 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000368414 | ENST00000513900 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000368414 | ENST00000515404 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000368414 | ENST00000522562 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-intron | ENST00000368414 | ENST00000522095 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| Frame-shift | ENST00000359704 | ENST00000261413 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| Frame-shift | ENST00000359704 | ENST00000457646 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| Frame-shift | ENST00000359704 | ENST00000513900 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| Frame-shift | ENST00000359704 | ENST00000515404 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| In-frame | ENST00000359704 | ENST00000522562 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| 5CDS-intron | ENST00000359704 | ENST00000522095 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000275184 | ENST00000261413 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000275184 | ENST00000457646 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000275184 | ENST00000513900 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000275184 | ENST00000515404 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-3CDS | ENST00000275184 | ENST00000522562 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
| intron-intron | ENST00000275184 | ENST00000522095 | RNF217 | chr6 | 125330430 | + | MRPS27 | chr5 | 71533957 | - |
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FusionProtFeatures for RNF217_MRPS27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF217 | MRPS27 |