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Fusion gene ID: 31493

FusionGeneSummary for RNF185_SFI1

Fusion gene summary

Fusion gene information	Fusion gene name: RNF185_SFI1
	Fusion gene ID: 31493
		Hgene	Tgene
	Gene symbol	RNF185	SFI1
	Gene ID	91445	9814
	Gene name	ring finger protein 185	SFI1 centrin binding protein
	Synonyms	-	PISD\|PPP1R139\|hSfi1p
	Cytomap	22q12.2	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase RNF185BSK65-MONO1BSK65-MONO2BSK65-PANC1BSK65-PANC2BSK65-TEST1BSK65-TEST2BSK65-TEST3RING-type E3 ubiquitin transferase RNF185	protein SFI1 homologSfi1 homolog, spindle assembly associatedhomolog of yeast Sfi1protein phosphatase 1, regulatory subunit 139
	Modification date	20180523	20180519
	UniProtAcc	Q96GF1	A8K8P3
	Ensembl transtripts involved in fusion gene	ENST00000426256, ENST00000326132, ENST00000266252,	ENST00000443326, ENST00000414585, ENST00000540643, ENST00000432498, ENST00000443011, ENST00000400289, ENST00000400288, ENST00000474741,
Fusion gene scores	* DoF score	10 X 6 X 7=420	5 X 4 X 4=80
	# samples	12	5
	** MAII score	log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RNF185 [Title/Abstract] AND SFI1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RNF185	GO:0051865	protein autoubiquitination	24019521
Tgene	SFI1	GO:0010923	negative regulation of phosphatase activity	19389623

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-C8-A12W-01A	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000426256	ENST00000443326	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000426256	ENST00000414585	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000426256	ENST00000540643	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000426256	ENST00000432498	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000426256	ENST00000443011	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000426256	ENST00000400289	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000426256	ENST00000400288	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-intron	ENST00000426256	ENST00000474741	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000326132	ENST00000443326	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000326132	ENST00000414585	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000326132	ENST00000540643	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000326132	ENST00000432498	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000326132	ENST00000443011	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000326132	ENST00000400289	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000326132	ENST00000400288	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-intron	ENST00000326132	ENST00000474741	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000266252	ENST00000443326	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000266252	ENST00000414585	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000266252	ENST00000540643	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000266252	ENST00000432498	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000266252	ENST00000443011	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000266252	ENST00000400289	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-3CDS	ENST00000266252	ENST00000400288	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+
5UTR-intron	ENST00000266252	ENST00000474741	RNF185	chr22	31556289	+	SFI1	chr22	31942847	+

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FusionProtFeatures for RNF185_SFI1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RNF185 Q96GF1	SFI1 A8K8P3

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Fusion gene ID: 31493

FusionGeneSummary for RNF185_SFI1

FusionProtFeatures for RNF185_SFI1