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Fusion gene ID: 31461 |
FusionGeneSummary for RNF166_EPN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF166_EPN2 | Fusion gene ID: 31461 | Hgene | Tgene | Gene symbol | RNF166 | EPN2 | Gene ID | 115992 | 22905 |
| Gene name | ring finger protein 166 | epsin 2 | |
| Synonyms | - | EHB21 | |
| Cytomap | 16q24.2-q24.3 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING finger protein 166 | epsin-2EPS-15-interacting protein 2Eps15 binding protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q96A37 | O95208 | |
| Ensembl transtripts involved in fusion gene | ENST00000312838, ENST00000537718, ENST00000541206, ENST00000568683, ENST00000567844, ENST00000562499, | ENST00000441293, ENST00000314728, ENST00000347697, ENST00000395618, ENST00000575595, ENST00000395620, ENST00000395626, ENST00000571254, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 9 X 9 X 5=405 |
| # samples | 2 | 10 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(10/405*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF166 [Title/Abstract] AND EPN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF870800 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000312838 | ENST00000441293 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000312838 | ENST00000314728 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000312838 | ENST00000347697 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000312838 | ENST00000395618 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000312838 | ENST00000575595 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000312838 | ENST00000395620 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000312838 | ENST00000395626 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000312838 | ENST00000571254 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000441293 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000314728 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000347697 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000395618 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000575595 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000395620 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000395626 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000537718 | ENST00000571254 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000441293 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000314728 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000347697 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000395618 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000575595 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000395620 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000395626 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000541206 | ENST00000571254 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000441293 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000314728 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000347697 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000395618 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000575595 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000395620 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000395626 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000568683 | ENST00000571254 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000441293 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000314728 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000347697 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000395618 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000575595 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000395620 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000395626 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000567844 | ENST00000571254 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000441293 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000314728 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000347697 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000395618 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000575595 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000395620 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000395626 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
| intron-intron | ENST00000562499 | ENST00000571254 | RNF166 | chr16 | 88766131 | + | EPN2 | chr17 | 19209450 | - |
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FusionProtFeatures for RNF166_EPN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF166 | EPN2 |