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Fusion gene ID: 31448 |
FusionGeneSummary for RNF149_C1orf43 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF149_C1orf43 | Fusion gene ID: 31448 | Hgene | Tgene | Gene symbol | RNF149 | C1orf43 | Gene ID | 284996 | 25912 |
| Gene name | ring finger protein 149 | chromosome 1 open reading frame 43 | |
| Synonyms | DNAPTP2 | HSPC012|NICE-3|NICE3|NS5ATP4|S863-3 | |
| Cytomap | 2q11.2 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF149DNA polymerase-transactivated protein 2RING-type E3 ubiquitin transferase RNF149 | uncharacterized protein C1orf43HCV NS5A-transactivated protein 4hepatitis C virus NS5A-transactivated protein 4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8NC42 | Q9BWL3 | |
| Ensembl transtripts involved in fusion gene | ENST00000485752, ENST00000295317, | ENST00000368521, ENST00000362076, ENST00000350592, ENST00000368519, ENST00000483282, ENST00000368518, ENST00000368516, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 4 X 4 X 3=48 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/50*10)=0.485426827170242 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF149 [Title/Abstract] AND C1orf43 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW391384 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000485752 | ENST00000368521 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000485752 | ENST00000362076 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000485752 | ENST00000350592 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000485752 | ENST00000368519 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000485752 | ENST00000483282 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000485752 | ENST00000368518 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000485752 | ENST00000368516 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000295317 | ENST00000368521 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000295317 | ENST00000362076 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000295317 | ENST00000350592 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000295317 | ENST00000368519 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000295317 | ENST00000483282 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000295317 | ENST00000368518 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
| intron-intron | ENST00000295317 | ENST00000368516 | RNF149 | chr2 | 101893937 | + | C1orf43 | chr1 | 154182122 | - |
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FusionProtFeatures for RNF149_C1orf43 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF149 | C1orf43 |