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Fusion gene ID: 31435 |
FusionGeneSummary for RNF141_RNF141 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF141_RNF141 | Fusion gene ID: 31435 | Hgene | Tgene | Gene symbol | RNF141 | RNF141 | Gene ID | 50862 | 50862 |
| Gene name | ring finger protein 141 | ring finger protein 141 | |
| Synonyms | RFP141|ZFP26|ZNF230 | RFP141|ZFP26|ZNF230 | |
| Cytomap | 11p15.4|11p15 | 11p15.4|11p15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING finger protein 141C3HC4-like zinc finger proteinzinc finger protein 230 | RING finger protein 141C3HC4-like zinc finger proteinzinc finger protein 230 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8WVD5 | Q8WVD5 | |
| Ensembl transtripts involved in fusion gene | ENST00000265981, ENST00000528665, | ENST00000265981, ENST00000528665, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 1=16 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RNF141 [Title/Abstract] AND RNF141 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF141 | GO:0051865 | protein autoubiquitination | 24105792 |
| Tgene | RNF141 | GO:0051865 | protein autoubiquitination | 24105792 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA314811 | RNF141 | chr11 | 10533839 | + | RNF141 | chr11 | 10533952 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000265981 | ENST00000265981 | RNF141 | chr11 | 10533839 | + | RNF141 | chr11 | 10533952 | - |
| intron-intron | ENST00000265981 | ENST00000528665 | RNF141 | chr11 | 10533839 | + | RNF141 | chr11 | 10533952 | - |
| intron-3UTR | ENST00000528665 | ENST00000265981 | RNF141 | chr11 | 10533839 | + | RNF141 | chr11 | 10533952 | - |
| intron-intron | ENST00000528665 | ENST00000528665 | RNF141 | chr11 | 10533839 | + | RNF141 | chr11 | 10533952 | - |
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FusionProtFeatures for RNF141_RNF141 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF141 | RNF141 |