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Fusion gene ID: 31406 |
FusionGeneSummary for RNF121_VPS37C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF121_VPS37C | Fusion gene ID: 31406 | Hgene | Tgene | Gene symbol | RNF121 | VPS37C | Gene ID | 55298 | 55048 |
| Gene name | ring finger protein 121 | VPS37C, ESCRT-I subunit | |
| Synonyms | - | - | |
| Cytomap | 11q13.4 | 11q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING finger protein 121 | vacuolar protein sorting-associated protein 37CESCRT-I complex subunit VPS37ChVps37Cvacuolar protein sorting 37 homolog Cvacuolar protein sorting 37C | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9H920 | A5D8V6 | |
| Ensembl transtripts involved in fusion gene | ENST00000361756, ENST00000533380, ENST00000393713, ENST00000490867, ENST00000545854, ENST00000530137, | ENST00000301765, | |
| Fusion gene scores | * DoF score | 14 X 4 X 7=392 | 5 X 3 X 4=60 |
| # samples | 15 | 5 | |
| ** MAII score | log2(15/392*10)=-1.38589115361933 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF121 [Title/Abstract] AND VPS37C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A1G4-01A | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361756 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| In-frame | ENST00000533380 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| In-frame | ENST00000393713 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| 3UTR-3CDS | ENST00000490867 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| 5UTR-3CDS | ENST00000545854 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
| In-frame | ENST00000530137 | ENST00000301765 | RNF121 | chr11 | 71671937 | + | VPS37C | chr11 | 60901679 | - |
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FusionProtFeatures for RNF121_VPS37C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RNF121 | VPS37C |