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Fusion gene ID: 3140

FusionGeneSummary for ATF7IP2_IQCK

Fusion gene summary

Fusion gene information	Fusion gene name: ATF7IP2_IQCK
	Fusion gene ID: 3140
		Hgene	Tgene
	Gene symbol	ATF7IP2	IQCK
	Gene ID	80063	124152
	Gene name	activating transcription factor 7 interacting protein 2	IQ motif containing K
	Synonyms	MCAF2	-
	Cytomap	16p13.2-p13.13	16p12.3
	Type of gene	protein-coding	protein-coding
	Description	activating transcription factor 7-interacting protein 2ATF7-interacting protein 2MBD1-containing chromatin associated factor 2	IQ domain-containing protein K
	Modification date	20180519	20180519
	UniProtAcc	Q5U623	Q8N0W5
	Ensembl transtripts involved in fusion gene	ENST00000396560, ENST00000396559, ENST00000561932, ENST00000543967, ENST00000356427, ENST00000324570,	ENST00000320394, ENST00000564186, ENST00000541926, ENST00000433597, ENST00000562762,
Fusion gene scores	* DoF score	2 X 2 X 1=4	3 X 5 X 3=45
	# samples	2	6
	** MAII score	log2(2/4*10)=2.32192809488736	log2(6/45*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ATF7IP2 [Title/Abstract] AND IQCK [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-13-0893-01B	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000396560	ENST00000320394	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000396560	ENST00000564186	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000396560	ENST00000541926	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000396560	ENST00000433597	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
5CDS-3UTR	ENST00000396560	ENST00000562762	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000396559	ENST00000320394	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000396559	ENST00000564186	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000396559	ENST00000541926	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000396559	ENST00000433597	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
5CDS-3UTR	ENST00000396559	ENST00000562762	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000561932	ENST00000320394	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000561932	ENST00000564186	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000561932	ENST00000541926	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000561932	ENST00000433597	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3UTR	ENST00000561932	ENST00000562762	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000543967	ENST00000320394	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000543967	ENST00000564186	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000543967	ENST00000541926	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3CDS	ENST00000543967	ENST00000433597	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
intron-3UTR	ENST00000543967	ENST00000562762	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000356427	ENST00000320394	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000356427	ENST00000564186	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000356427	ENST00000541926	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000356427	ENST00000433597	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
5CDS-3UTR	ENST00000356427	ENST00000562762	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000324570	ENST00000320394	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000324570	ENST00000564186	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000324570	ENST00000541926	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
In-frame	ENST00000324570	ENST00000433597	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+
5CDS-3UTR	ENST00000324570	ENST00000562762	ATF7IP2	chr16	10534319	+	IQCK	chr16	19775170	+

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FusionProtFeatures for ATF7IP2_IQCK

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATF7IP2 Q5U623	IQCK Q8N0W5

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Fusion gene ID: 3140

FusionGeneSummary for ATF7IP2_IQCK

FusionProtFeatures for ATF7IP2_IQCK