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Fusion gene ID: 31333 |
FusionGeneSummary for RMND5A_MALAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RMND5A_MALAT1 | Fusion gene ID: 31333 | Hgene | Tgene | Gene symbol | RMND5A | MALAT1 | Gene ID | 64795 | 378938 |
| Gene name | required for meiotic nuclear division 5 homolog A | metastasis associated lung adenocarcinoma transcript 1 | |
| Synonyms | CTLH|GID2|GID2A|RMD5|p44CTLH | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | |
| Cytomap | 2p11.2 | 11q13.1 | |
| Type of gene | protein-coding | ncRNA | |
| Description | protein RMD5 homolog A44-kD protein coding for CTLH motifC-terminal to LisH motif, 44 kDaGID complex subunit 2 homolog A | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9H871 | ||
| Ensembl transtripts involved in fusion gene | ENST00000283632, ENST00000472843, | ENST00000534336, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 71 X 110 X 1=7810 |
| # samples | 4 | 126 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(126/7810*10)=-2.63189881464206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RMND5A [Title/Abstract] AND MALAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | W32517 | RMND5A | chr2 | 87004587 | - | MALAT1 | chr11 | 65267943 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000283632 | ENST00000534336 | RMND5A | chr2 | 87004587 | - | MALAT1 | chr11 | 65267943 | - |
| intron-3UTR | ENST00000472843 | ENST00000534336 | RMND5A | chr2 | 87004587 | - | MALAT1 | chr11 | 65267943 | - |
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FusionProtFeatures for RMND5A_MALAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RMND5A | MALAT1 |