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Fusion gene ID: 31313 |
FusionGeneSummary for RMDN3_PLD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RMDN3_PLD1 | Fusion gene ID: 31313 | Hgene | Tgene | Gene symbol | RMDN3 | PLD1 | Gene ID | 55177 | 5589 |
| Gene name | regulator of microtubule dynamics 3 | protein kinase C substrate 80K-H | |
| Synonyms | FAM82A2|FAM82C|RMD-3|RMD3|ptpip51 | AGE-R2|G19P1|GIIB|PCLD|PCLD1|PKCSH|PLD1|VASAP-60 | |
| Cytomap | 15q15.1 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | regulator of microtubule dynamics protein 3TCPTP-interacting protein 51cerebral protein 10family with sequence similarity 82, member A2family with sequence similarity 82, member Cmicrotubule-associated proteinprotein tyrosine phosphatase-interacting | glucosidase 2 subunit betaAGE-binding receptor 2advanced glycation end-product receptor 2glucosidase II subunit betahepatocystinprotein kinase C substrate 60.1 kDa protein heavy chainprotein kinase C substrate, 80 Kda protein | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q96TC7 | Q13393 | |
| Ensembl transtripts involved in fusion gene | ENST00000260385, ENST00000338376, ENST00000558560, | ENST00000356327, ENST00000351298, ENST00000342215, ENST00000340989, ENST00000497307, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 4 X 3=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RMDN3 [Title/Abstract] AND PLD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW862982 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000260385 | ENST00000356327 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000260385 | ENST00000351298 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000260385 | ENST00000342215 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000260385 | ENST00000340989 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000260385 | ENST00000497307 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000338376 | ENST00000356327 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000338376 | ENST00000351298 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000338376 | ENST00000342215 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000338376 | ENST00000340989 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000338376 | ENST00000497307 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000558560 | ENST00000356327 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000558560 | ENST00000351298 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000558560 | ENST00000342215 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000558560 | ENST00000340989 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
| intron-intron | ENST00000558560 | ENST00000497307 | RMDN3 | chr15 | 41028455 | + | PLD1 | chr3 | 171445323 | + |
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FusionProtFeatures for RMDN3_PLD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RMDN3 | PLD1 |