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Fusion gene ID: 31300

FusionGeneSummary for RLF_MFSD2A

Fusion gene summary

Fusion gene information	Fusion gene name: RLF_MFSD2A
	Fusion gene ID: 31300
		Hgene	Tgene
	Gene symbol	RLF	MFSD2A
	Gene ID	6018	84879
	Gene name	rearranged L-myc fusion	major facilitator superfamily domain containing 2A
	Synonyms	ZN-15L\|ZNF292L	MCPH15\|MFSD2\|NLS1
	Cytomap	1p34.2	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein RlfZn-15 relatedrearranged L-myc fusion gene proteinrearranged L-myc fusion sequencezn-15-related protein	sodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1
	Modification date	20180519	20180329
	UniProtAcc	Q13129	Q8NA29
	Ensembl transtripts involved in fusion gene	ENST00000372771,	ENST00000372811, ENST00000420632, ENST00000372809, ENST00000480630,
Fusion gene scores	* DoF score	11 X 6 X 6=396	6 X 6 X 3=108
	# samples	11	7
	** MAII score	log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RLF [Title/Abstract] AND MFSD2A [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RLF	GO:0015074	DNA integration	1851085
Hgene	RLF	GO:0051276	chromosome organization	1649386
Tgene	MFSD2A	GO:0051977	lysophospholipid transport	24828044

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	OV	TCGA-24-1557-01A	RLF	chr1	40627308	+	MFSD2A	chr1	40424373	+
TCGA	LD	OV	TCGA-24-1557-01A	RLF	chr1	40627308	+	MFSD2A	chr1	40422759	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000372771	ENST00000372811	RLF	chr1	40627308	+	MFSD2A	chr1	40424373	+
5CDS-intron	ENST00000372771	ENST00000420632	RLF	chr1	40627308	+	MFSD2A	chr1	40424373	+
5CDS-intron	ENST00000372771	ENST00000372809	RLF	chr1	40627308	+	MFSD2A	chr1	40424373	+
5CDS-intron	ENST00000372771	ENST00000480630	RLF	chr1	40627308	+	MFSD2A	chr1	40424373	+
In-frame	ENST00000372771	ENST00000372811	RLF	chr1	40627308	+	MFSD2A	chr1	40422759	+
5CDS-intron	ENST00000372771	ENST00000420632	RLF	chr1	40627308	+	MFSD2A	chr1	40422759	+
5CDS-intron	ENST00000372771	ENST00000372809	RLF	chr1	40627308	+	MFSD2A	chr1	40422759	+
5CDS-intron	ENST00000372771	ENST00000480630	RLF	chr1	40627308	+	MFSD2A	chr1	40422759	+

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FusionProtFeatures for RLF_MFSD2A

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RLF Q13129	MFSD2A Q8NA29

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Fusion gene ID: 31300

FusionGeneSummary for RLF_MFSD2A

FusionProtFeatures for RLF_MFSD2A