|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 31298 |
FusionGeneSummary for RLF_IREB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RLF_IREB2 | Fusion gene ID: 31298 | Hgene | Tgene | Gene symbol | RLF | IREB2 | Gene ID | 6018 | 3658 |
| Gene name | rearranged L-myc fusion | iron responsive element binding protein 2 | |
| Synonyms | ZN-15L|ZNF292L | ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD | |
| Cytomap | 1p34.2 | 15q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein RlfZn-15 relatedrearranged L-myc fusion gene proteinrearranged L-myc fusion sequencezn-15-related protein | iron-responsive element-binding protein 2iron regulatory protein 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q13129 | P48200 | |
| Ensembl transtripts involved in fusion gene | ENST00000372771, | ENST00000258886, ENST00000560440, ENST00000559427, | |
| Fusion gene scores | * DoF score | 11 X 6 X 6=396 | 3 X 3 X 1=9 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RLF [Title/Abstract] AND IREB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RLF | GO:0015074 | DNA integration | 1851085 |
| Hgene | RLF | GO:0051276 | chromosome organization | 1649386 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW856369 | RLF | chr1 | 40649893 | + | IREB2 | chr15 | 78766921 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000372771 | ENST00000258886 | RLF | chr1 | 40649893 | + | IREB2 | chr15 | 78766921 | + |
| intron-3UTR | ENST00000372771 | ENST00000560440 | RLF | chr1 | 40649893 | + | IREB2 | chr15 | 78766921 | + |
| intron-intron | ENST00000372771 | ENST00000559427 | RLF | chr1 | 40649893 | + | IREB2 | chr15 | 78766921 | + |
Top |
FusionProtFeatures for RLF_IREB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RLF | IREB2 |