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Fusion gene ID: 31267 |
FusionGeneSummary for RIMS2_ODF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RIMS2_ODF1 | Fusion gene ID: 31267 | Hgene | Tgene | Gene symbol | RIMS2 | ODF1 | Gene ID | 9699 | 4956 |
| Gene name | regulating synaptic membrane exocytosis 2 | outer dense fiber of sperm tails 1 | |
| Synonyms | OBOE|RAB3IP3|RIM2 | CT133|HSPB10|ODF|ODF2|ODF27|ODFP|ODFPG|ODFPGA|ODFPGB|RT7|SODF | |
| Cytomap | 8q22.3 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | regulating synaptic membrane exocytosis protein 2RAB3 interacting protein 3Rab3-interacting proteinnon-small cell lung cancer RimL3a proteinnon-small cell lung cancer RimL3c proteinnuclear proteinrab-3-interacting molecule 2rab-3-interacting protei | outer dense fiber protein 1cancer/testis antigen 133heat shock protein beta-10outer dense fiber of sperm tails, 27-kD | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UQ26 | Q14990 | |
| Ensembl transtripts involved in fusion gene | ENST00000406091, ENST00000262231, ENST00000507740, ENST00000522174, ENST00000436393, ENST00000339750, | ENST00000285402, ENST00000518835, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 4 X 1 X 3=12 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RIMS2 [Title/Abstract] AND ODF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RIMS2 | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E9-A22B-01A | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000406091 | ENST00000285402 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| 5CDS-intron | ENST00000406091 | ENST00000518835 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-3CDS | ENST00000262231 | ENST00000285402 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-intron | ENST00000262231 | ENST00000518835 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-3CDS | ENST00000507740 | ENST00000285402 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-intron | ENST00000507740 | ENST00000518835 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-3CDS | ENST00000522174 | ENST00000285402 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-intron | ENST00000522174 | ENST00000518835 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-3CDS | ENST00000436393 | ENST00000285402 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-intron | ENST00000436393 | ENST00000518835 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-3CDS | ENST00000339750 | ENST00000285402 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
| intron-intron | ENST00000339750 | ENST00000518835 | RIMS2 | chr8 | 104513290 | + | ODF1 | chr8 | 103572680 | + |
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FusionProtFeatures for RIMS2_ODF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RIMS2 | ODF1 |