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Fusion gene ID: 31242 |
FusionGeneSummary for RIF1_PDE11A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RIF1_PDE11A | Fusion gene ID: 31242 | Hgene | Tgene | Gene symbol | RIF1 | PDE11A | Gene ID | 55791 | 50940 |
| Gene name | ligand dependent nuclear receptor interacting factor 1 | phosphodiesterase 11A | |
| Synonyms | C1orf103|RIF1 | PPNAD2 | |
| Cytomap | 1p13.3 | 2q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ligand-dependent nuclear receptor-interacting factor 1receptor-interacting factor 1 | dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AcAMP and cGMP cyclic nucleotide phosphodiesterase 11A | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q5UIP0 | Q9HCR9 | |
| Ensembl transtripts involved in fusion gene | ENST00000444746, ENST00000453091, ENST00000428287, ENST00000243326, ENST00000430328, ENST00000433166, ENST00000457745, | ENST00000286063, ENST00000358450, ENST00000450799, ENST00000409504, ENST00000389683, ENST00000449286, ENST00000497003, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 8 X 4 X 6=192 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RIF1 [Title/Abstract] AND PDE11A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AJ-A3NF-01A | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000444746 | ENST00000286063 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000444746 | ENST00000358450 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000444746 | ENST00000450799 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000444746 | ENST00000409504 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000444746 | ENST00000389683 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000444746 | ENST00000449286 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-5UTR | ENST00000444746 | ENST00000497003 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000453091 | ENST00000286063 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000453091 | ENST00000358450 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000453091 | ENST00000450799 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000453091 | ENST00000409504 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000453091 | ENST00000389683 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000453091 | ENST00000449286 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-5UTR | ENST00000453091 | ENST00000497003 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000428287 | ENST00000286063 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000428287 | ENST00000358450 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000428287 | ENST00000450799 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000428287 | ENST00000409504 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000428287 | ENST00000389683 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000428287 | ENST00000449286 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-5UTR | ENST00000428287 | ENST00000497003 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000243326 | ENST00000286063 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000243326 | ENST00000358450 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000243326 | ENST00000450799 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000243326 | ENST00000409504 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000243326 | ENST00000389683 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000243326 | ENST00000449286 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-5UTR | ENST00000243326 | ENST00000497003 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000430328 | ENST00000286063 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| In-frame | ENST00000430328 | ENST00000358450 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000430328 | ENST00000450799 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000430328 | ENST00000409504 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000430328 | ENST00000389683 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-intron | ENST00000430328 | ENST00000449286 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| 5CDS-5UTR | ENST00000430328 | ENST00000497003 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-3CDS | ENST00000433166 | ENST00000286063 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-3CDS | ENST00000433166 | ENST00000358450 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000433166 | ENST00000450799 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000433166 | ENST00000409504 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000433166 | ENST00000389683 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000433166 | ENST00000449286 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-5UTR | ENST00000433166 | ENST00000497003 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-3CDS | ENST00000457745 | ENST00000286063 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-3CDS | ENST00000457745 | ENST00000358450 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000457745 | ENST00000450799 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000457745 | ENST00000409504 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000457745 | ENST00000389683 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-intron | ENST00000457745 | ENST00000449286 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
| intron-5UTR | ENST00000457745 | ENST00000497003 | RIF1 | chr2 | 152318980 | + | PDE11A | chr2 | 178592900 | - |
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FusionProtFeatures for RIF1_PDE11A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RIF1 | PDE11A |