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Fusion gene ID: 31218 |
FusionGeneSummary for RHPN2_CLASRP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RHPN2_CLASRP | Fusion gene ID: 31218 | Hgene | Tgene | Gene symbol | RHPN2 | CLASRP | Gene ID | 85415 | 11129 |
| Gene name | rhophilin Rho GTPase binding protein 2 | CLK4 associating serine/arginine rich protein | |
| Synonyms | P76RBE|RHOBP | CLASP|SFRS16|SWAP2 | |
| Cytomap | 19q13.11 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rhophilin-276 kDa RhoB effector proteinGTP-Rho-binding protein 2rhophilin-like Rho-GTPase binding protein | CLK4-associating serine/arginine rich proteinClk4 associating SR-related proteinsplicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)suppressor of white apricot homolog 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8IUC4 | Q8N2M8 | |
| Ensembl transtripts involved in fusion gene | ENST00000254260, ENST00000400226, ENST00000588683, | ENST00000221455, ENST00000391953, ENST00000544944, | |
| Fusion gene scores | * DoF score | 13 X 7 X 9=819 | 6 X 7 X 5=210 |
| # samples | 14 | 7 | |
| ** MAII score | log2(14/819*10)=-2.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RHPN2 [Title/Abstract] AND CLASRP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-L5-A43I-01A | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000254260 | ENST00000221455 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| Frame-shift | ENST00000254260 | ENST00000391953 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| Frame-shift | ENST00000254260 | ENST00000544944 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| 5UTR-3CDS | ENST00000400226 | ENST00000221455 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| 5UTR-3CDS | ENST00000400226 | ENST00000391953 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| 5UTR-3CDS | ENST00000400226 | ENST00000544944 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| intron-3CDS | ENST00000588683 | ENST00000221455 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| intron-3CDS | ENST00000588683 | ENST00000391953 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
| intron-3CDS | ENST00000588683 | ENST00000544944 | RHPN2 | chr19 | 33517410 | - | CLASRP | chr19 | 45573795 | + |
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FusionProtFeatures for RHPN2_CLASRP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RHPN2 | CLASRP |