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Fusion gene ID: 31202 |
FusionGeneSummary for RHOT1_ASIC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RHOT1_ASIC2 | Fusion gene ID: 31202 | Hgene | Tgene | Gene symbol | RHOT1 | ASIC2 | Gene ID | 55288 | 40 |
| Gene name | ras homolog family member T1 | acid sensing ion channel subunit 2 | |
| Synonyms | ARHT1|MIRO-1|MIRO1 | ACCN|ACCN1|ASIC2a|BNC1|BNaC1|MDEG|hBNaC1 | |
| Cytomap | 17q11.2 | 17q11.2-q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitochondrial Rho GTPase 1mitochondrial Rho (MIRO) GTPase 1rac-GTP binding protein-like proteinras homolog gene family, member T1 | acid-sensing ion channel 2acid sensing (proton gated) ion channel 2amiloride-sensitive cation channel 1, neuronalbrain sodium channel 1mammalian degenerin homologneuronal amiloride-sensitive cation channel 1 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q8IXI2 | Q16515 | |
| Ensembl transtripts involved in fusion gene | ENST00000333942, ENST00000358365, ENST00000583994, ENST00000545287, ENST00000354266, ENST00000394692, ENST00000581094, ENST00000580976, | ENST00000225823, ENST00000359872, ENST00000448983, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 10 X 9 X 5=450 |
| # samples | 8 | 12 | |
| ** MAII score | log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RHOT1 [Title/Abstract] AND ASIC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-0174-01A | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000333942 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000333942 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5CDS-5UTR | ENST00000333942 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000358365 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000358365 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5CDS-5UTR | ENST00000358365 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5UTR-3CDS | ENST00000583994 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5UTR-3CDS | ENST00000583994 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5UTR-5UTR | ENST00000583994 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000545287 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000545287 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5CDS-5UTR | ENST00000545287 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5UTR-3CDS | ENST00000354266 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5UTR-3CDS | ENST00000354266 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5UTR-5UTR | ENST00000354266 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000394692 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000394692 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5CDS-5UTR | ENST00000394692 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000581094 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| Frame-shift | ENST00000581094 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 5CDS-5UTR | ENST00000581094 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 3UTR-3CDS | ENST00000580976 | ENST00000225823 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 3UTR-3CDS | ENST00000580976 | ENST00000359872 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
| 3UTR-5UTR | ENST00000580976 | ENST00000448983 | RHOT1 | chr17 | 30469748 | + | ASIC2 | chr17 | 31439085 | - |
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FusionProtFeatures for RHOT1_ASIC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RHOT1 | ASIC2 |