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Fusion gene ID: 31182 |
FusionGeneSummary for RHOB_CLPTM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RHOB_CLPTM1 | Fusion gene ID: 31182 | Hgene | Tgene | Gene symbol | RHOB | CLPTM1 | Gene ID | 388 | 1209 |
| Gene name | ras homolog family member B | CLPTM1, transmembrane protein | |
| Synonyms | ARH6|ARHB|MST081|MSTP081|RHOH6 | - | |
| Cytomap | 2p24.1 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-related GTP-binding protein RhoBAplysia RAS-related homolog 6h6oncogene RHO H6ras homolog gene family, member Brho cDNA clone 6 | cleft lip and palate transmembrane protein 1cleft lip and palate associated transmembrane protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P62745 | O96005 | |
| Ensembl transtripts involved in fusion gene | ENST00000272233, | ENST00000546079, ENST00000541297, ENST00000337392, ENST00000589158, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RHOB [Title/Abstract] AND CLPTM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RHOB | GO:0008333 | endosome to lysosome transport | 10508588 |
| Hgene | RHOB | GO:0030336 | negative regulation of cell migration | 20460403 |
| Hgene | RHOB | GO:0070301 | cellular response to hydrogen peroxide | 21373644 |
| Hgene | RHOB | GO:0071479 | cellular response to ionizing radiation | 21373644 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF855458 | RHOB | chr2 | 20648064 | - | CLPTM1 | chr19 | 45495560 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000272233 | ENST00000546079 | RHOB | chr2 | 20648064 | - | CLPTM1 | chr19 | 45495560 | + |
| 3UTR-3CDS | ENST00000272233 | ENST00000541297 | RHOB | chr2 | 20648064 | - | CLPTM1 | chr19 | 45495560 | + |
| 3UTR-3CDS | ENST00000272233 | ENST00000337392 | RHOB | chr2 | 20648064 | - | CLPTM1 | chr19 | 45495560 | + |
| 3UTR-intron | ENST00000272233 | ENST00000589158 | RHOB | chr2 | 20648064 | - | CLPTM1 | chr19 | 45495560 | + |
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FusionProtFeatures for RHOB_CLPTM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RHOB | CLPTM1 |