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Fusion gene ID: 31156 |
FusionGeneSummary for RHCG_ITGA6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RHCG_ITGA6 | Fusion gene ID: 31156 | Hgene | Tgene | Gene symbol | RHCG | ITGA6 | Gene ID | 51458 | 3655 |
| Gene name | Rh family C glycoprotein | integrin subunit alpha 6 | |
| Synonyms | C15orf6|PDRC2|RHGK|SLC42A3 | CD49f|ITGA6B|VLA-6 | |
| Cytomap | 15q26.1 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ammonium transporter Rh type CRh type C glycoproteinRhesus blood group, C glycoproteinrh family type C glycoproteinrh glycoprotein kidneyrhesus blood group family type C glycoproteintumor-related protein DRC2 | integrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9UBD6 | P23229 | |
| Ensembl transtripts involved in fusion gene | ENST00000544600, ENST00000268122, | ENST00000409532, ENST00000264107, ENST00000343713, ENST00000264106, ENST00000375221, ENST00000409080, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 3 X 2=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RHCG [Title/Abstract] AND ITGA6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RHCG | GO:0006873 | cellular ion homeostasis | 14761968 |
| Hgene | RHCG | GO:0015696 | ammonium transport | 14761968|15929723|16580862|18032481 |
| Hgene | RHCG | GO:0070634 | transepithelial ammonium transport | 18032481 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI141812 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000544600 | ENST00000409532 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000544600 | ENST00000264107 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000544600 | ENST00000343713 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000544600 | ENST00000264106 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000544600 | ENST00000375221 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000544600 | ENST00000409080 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000268122 | ENST00000409532 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000268122 | ENST00000264107 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000268122 | ENST00000343713 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000268122 | ENST00000264106 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000268122 | ENST00000375221 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
| intron-3CDS | ENST00000268122 | ENST00000409080 | RHCG | chr15 | 90014889 | + | ITGA6 | chr2 | 173349949 | - |
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FusionProtFeatures for RHCG_ITGA6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RHCG | ITGA6 |