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Fusion gene ID: 31052 |
FusionGeneSummary for RFX1_CEACAMP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RFX1_CEACAMP3 | Fusion gene ID: 31052 | Hgene | Tgene | Gene symbol | RFX1 | CEACAMP3 | Gene ID | 5989 | 1092 |
| Gene name | regulatory factor X1 | carcinoembryonic antigen related cell adhesion molecule pseudogene 3 | |
| Synonyms | EFC|RFX | CEACAM24P|CGM10 | |
| Cytomap | 19p13.12 | 19q13.2 | |
| Type of gene | protein-coding | pseudo | |
| Description | MHC class II regulatory factor RFX1MHC class II regulatory factor RFXenhancer factor Cregulatory factor X, 1 (influences HLA class II expression)trans-acting regulatory factor 1transcription factor RFX1 | carcinoembryonic antigen gene family member 10 (pseudogene)carcinoembryonic antigen-related cell adhesion molecule 24, pseudogene | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | P22670 | ||
| Ensembl transtripts involved in fusion gene | ENST00000254325, ENST00000586913, | ENST00000473762, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 3 X 3=27 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RFX1 [Title/Abstract] AND CEACAMP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-29-1710-01A | RFX1 | chr19 | 14083555 | - | CEACAMP3 | chr19 | 42111196 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000254325 | ENST00000473762 | RFX1 | chr19 | 14083555 | - | CEACAMP3 | chr19 | 42111196 | + |
| intron-3UTR | ENST00000586913 | ENST00000473762 | RFX1 | chr19 | 14083555 | - | CEACAMP3 | chr19 | 42111196 | + |
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FusionProtFeatures for RFX1_CEACAMP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RFX1 | CEACAMP3 |