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Fusion gene ID: 30989 |
FusionGeneSummary for REST_UFD1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REST_UFD1L | Fusion gene ID: 30989 | Hgene | Tgene | Gene symbol | REST | UFD1L | Gene ID | 5978 |
| Gene name | RE1 silencing transcription factor | ||
| Synonyms | GINGF5|HGF5|NRSF|WT6|XBR | ||
| Cytomap | 4q12 | ||
| Type of gene | protein-coding | ||
| Description | RE1-silencing transcription factorneural-restrictive silencer factorneuron restrictive silencer factorrepressor binding to the X2 box | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q13127 | ||
| Ensembl transtripts involved in fusion gene | ENST00000309042, ENST00000514063, | ENST00000263202, ENST00000360834, ENST00000399523, ENST00000484101, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: REST [Title/Abstract] AND UFD1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | REST | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8568247|21284946 |
| Hgene | REST | GO:0043922 | negative regulation by host of viral transcription | 17555596 |
| Hgene | REST | GO:0045892 | negative regulation of transcription, DNA-templated | 7697725|10449787|10734093|17984088|19342457 |
| Hgene | REST | GO:0045893 | positive regulation of transcription, DNA-templated | 17984088 |
| Hgene | REST | GO:0070933 | histone H4 deacetylation | 17555596 |
| Hgene | REST | GO:0071385 | cellular response to glucocorticoid stimulus | 17984088 |