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Fusion gene ID: 30986 |
FusionGeneSummary for REST_CNOT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REST_CNOT1 | Fusion gene ID: 30986 | Hgene | Tgene | Gene symbol | REST | CNOT1 | Gene ID | 5978 | 23019 |
| Gene name | RE1 silencing transcription factor | CCR4-NOT transcription complex subunit 1 | |
| Synonyms | GINGF5|HGF5|NRSF|WT6|XBR | AD-005|CDC39|NOT1|NOT1H | |
| Cytomap | 4q12 | 16q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RE1-silencing transcription factorneural-restrictive silencer factorneuron restrictive silencer factorrepressor binding to the X2 box | CCR4-NOT transcription complex subunit 1CCR4-associated factor 1NOT1 (negative regulator of transcription 1, yeast) homologadrenal gland protein AD-005negative regulator of transcription subunit 1 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13127 | A5YKK6 | |
| Ensembl transtripts involved in fusion gene | ENST00000309042, ENST00000514063, | ENST00000317147, ENST00000569240, ENST00000441024, ENST00000569732, ENST00000245138, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 4 X 5 X 3=60 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: REST [Title/Abstract] AND CNOT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | REST | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8568247|21284946 |
| Hgene | REST | GO:0043922 | negative regulation by host of viral transcription | 17555596 |
| Hgene | REST | GO:0045892 | negative regulation of transcription, DNA-templated | 7697725|10449787|10734093|17984088|19342457 |
| Hgene | REST | GO:0045893 | positive regulation of transcription, DNA-templated | 17984088 |
| Hgene | REST | GO:0070933 | histone H4 deacetylation | 17555596 |
| Hgene | REST | GO:0071385 | cellular response to glucocorticoid stimulus | 17984088 |
| Tgene | CNOT1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16778766 |
| Tgene | CNOT1 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly | 21976065 |
| Tgene | CNOT1 | GO:0017148 | negative regulation of translation | 24736845 |
| Tgene | CNOT1 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 16778766 |
| Tgene | CNOT1 | GO:0035195 | gene silencing by miRNA | 23172285|24768540 |
| Tgene | CNOT1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | 16778766 |
| Tgene | CNOT1 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 23644599 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | U22680 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000309042 | ENST00000317147 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| 3UTR-3CDS | ENST00000309042 | ENST00000569240 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| 3UTR-intron | ENST00000309042 | ENST00000441024 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| 3UTR-intron | ENST00000309042 | ENST00000569732 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| 3UTR-intron | ENST00000309042 | ENST00000245138 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| intron-3CDS | ENST00000514063 | ENST00000317147 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| intron-3CDS | ENST00000514063 | ENST00000569240 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| intron-intron | ENST00000514063 | ENST00000441024 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| intron-intron | ENST00000514063 | ENST00000569732 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
| intron-intron | ENST00000514063 | ENST00000245138 | REST | chr4 | 57800857 | + | CNOT1 | chr16 | 58559926 | + |
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FusionProtFeatures for REST_CNOT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| REST | CNOT1 |