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Fusion gene ID: 30958 |
FusionGeneSummary for REPS2_GLRA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REPS2_GLRA2 | Fusion gene ID: 30958 | Hgene | Tgene | Gene symbol | REPS2 | GLRA2 | Gene ID | 9185 | 2742 |
| Gene name | RALBP1 associated Eps domain containing 2 | glycine receptor alpha 2 | |
| Synonyms | POB1 | GLR | |
| Cytomap | Xp22.2 | Xp22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ralBP1-associated Eps domain-containing protein 2RALBP1-interacting protein 2partner of Ral-binding protein 1partner of RalBP1 | glycine receptor subunit alpha-2glycine receptor alpha 2 subunitglycine receptor, alpha-2 polypeptide | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8NFH8 | P23416 | |
| Ensembl transtripts involved in fusion gene | ENST00000357277, ENST00000303843, ENST00000380064, ENST00000469714, | ENST00000443437, ENST00000218075, ENST00000355020, | |
| Fusion gene scores | * DoF score | 7 X 5 X 8=280 | 1 X 1 X 1=1 |
| # samples | 12 | 1 | |
| ** MAII score | log2(12/280*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: REPS2 [Title/Abstract] AND GLRA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GLRA2 | GO:0007218 | neuropeptide signaling pathway | 2155780 |
| Tgene | GLRA2 | GO:0034220 | ion transmembrane transport | 2155780 |
| Tgene | GLRA2 | GO:0071230 | cellular response to amino acid stimulus | 2155780 |
| Tgene | GLRA2 | GO:0071294 | cellular response to zinc ion | 23895467 |
| Tgene | GLRA2 | GO:0071361 | cellular response to ethanol | 23895467 |
| Tgene | GLRA2 | GO:1902476 | chloride transmembrane transport | 23895467 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-X6-A8C6-01A | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000357277 | ENST00000443437 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000357277 | ENST00000218075 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000357277 | ENST00000355020 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000303843 | ENST00000443437 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000303843 | ENST00000218075 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000303843 | ENST00000355020 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000380064 | ENST00000443437 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000380064 | ENST00000218075 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| In-frame | ENST00000380064 | ENST00000355020 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| 3UTR-3CDS | ENST00000469714 | ENST00000443437 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| 3UTR-3CDS | ENST00000469714 | ENST00000218075 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
| 3UTR-3CDS | ENST00000469714 | ENST00000355020 | REPS2 | chrX | 17121902 | + | GLRA2 | chrX | 14708832 | + |
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FusionProtFeatures for REPS2_GLRA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| REPS2 | GLRA2 |