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Fusion gene ID: 30948 |
FusionGeneSummary for REL_RAB1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REL_RAB1A | Fusion gene ID: 30948 | Hgene | Tgene | Gene symbol | REL | RAB1A | Gene ID | 5966 | 5861 |
| Gene name | REL proto-oncogene, NF-kB subunit | RAB1A, member RAS oncogene family | |
| Synonyms | C-Rel | RAB1|YPT1 | |
| Cytomap | 2p16.1 | 2p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proto-oncogene c-Reloncogene REL, avian reticuloendotheliosisv-rel avian reticuloendotheliosis viral oncogene homolog | ras-related protein Rab-1AGTP binding protein Rab1aRAB1, member RAS oncogene familyRab GTPase YPT1 homologYPT1-related protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q04864 | P62820 | |
| Ensembl transtripts involved in fusion gene | ENST00000295025, ENST00000394479, | ENST00000494188, ENST00000409892, ENST00000409784, ENST00000398529, ENST00000409751, ENST00000260638, ENST00000356214, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 6 X 4 X 6=144 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: REL [Title/Abstract] AND RAB1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | REL | GO:0010629 | negative regulation of gene expression | 22065573 |
| Hgene | REL | GO:0032688 | negative regulation of interferon-beta production | 22065573 |
| Hgene | REL | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1406630 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-77-8009-01A | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000295025 | ENST00000494188 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000295025 | ENST00000409892 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000295025 | ENST00000409784 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000295025 | ENST00000398529 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000295025 | ENST00000409751 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000295025 | ENST00000260638 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000295025 | ENST00000356214 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000394479 | ENST00000494188 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000394479 | ENST00000409892 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000394479 | ENST00000409784 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000394479 | ENST00000398529 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000394479 | ENST00000409751 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000394479 | ENST00000260638 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
| 5CDS-5UTR | ENST00000394479 | ENST00000356214 | REL | chr2 | 61128218 | + | RAB1A | chr2 | 65331940 | - |
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FusionProtFeatures for REL_RAB1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| REL | RAB1A |