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Fusion gene ID: 30880 |
FusionGeneSummary for RCOR1_AMN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RCOR1_AMN | Fusion gene ID: 30880 | Hgene | Tgene | Gene symbol | RCOR1 | AMN | Gene ID | 23186 | 81693 |
| Gene name | REST corepressor 1 | amnion associated transmembrane protein | |
| Synonyms | COREST|RCOR | PRO1028|amnionless | |
| Cytomap | 14q32.31-q32.32 | 14q32.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | REST corepressor 1 | protein amnionlessamnionless homologvisceral endoderm-specific type 1 transmembrane protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UKL0 | Q9BXJ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000262241, ENST00000570597, | ENST00000299155, | |
| Fusion gene scores | * DoF score | 8 X 8 X 10=640 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/640*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RCOR1 [Title/Abstract] AND AMN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RCOR1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10449787 |
| Hgene | RCOR1 | GO:0070933 | histone H4 deacetylation | 17555596 |
| Tgene | AMN | GO:0006898 | receptor-mediated endocytosis | 14576052 |
| Tgene | AMN | GO:0015889 | cobalamin transport | 14576052 |
| Tgene | AMN | GO:0043001 | Golgi to plasma membrane protein transport | 14576052 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A928-01A | RCOR1 | chr14 | 103059662 | + | AMN | chr14 | 103390048 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262241 | ENST00000299155 | RCOR1 | chr14 | 103059662 | + | AMN | chr14 | 103390048 | + |
| In-frame | ENST00000570597 | ENST00000299155 | RCOR1 | chr14 | 103059662 | + | AMN | chr14 | 103390048 | + |
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FusionProtFeatures for RCOR1_AMN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RCOR1 | AMN |