|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 30879 |
FusionGeneSummary for RCN3_PAPPA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RCN3_PAPPA | Fusion gene ID: 30879 | Hgene | Tgene | Gene symbol | RCN3 | PAPPA | Gene ID | 57333 | 5069 |
| Gene name | reticulocalbin 3 | pappalysin 1 | |
| Synonyms | RLP49 | ASBABP2|DIPLA1|IGFBP-4ase|PAPA|PAPP-A|PAPPA1 | |
| Cytomap | 19q13.33 | 9q33.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | reticulocalbin-3EF-hand calcium-binding protein RLP49reticulocabinreticulocalbin 3, EF-hand calcium binding domain | pappalysin-1IGF-dependent IGFBP-4 proteaseaspecific BCL2 ARE-binding protein 2differentially placenta 1 expressed proteininsulin-like growth factor-dependent IGF binding protein-4 proteasepregnancy-associated plasma protein A, pappalysin 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96D15 | Q13219 | |
| Ensembl transtripts involved in fusion gene | ENST00000270645, ENST00000593644, | ENST00000328252, ENST00000534838, ENST00000483254, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 12 X 16 X 1=192 |
| # samples | 2 | 19 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(19/192*10)=-0.0151068923902084 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RCN3 [Title/Abstract] AND PAPPA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW962470 | RCN3 | chr19 | 50046507 | + | PAPPA | chr9 | 119163118 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000270645 | ENST00000328252 | RCN3 | chr19 | 50046507 | + | PAPPA | chr9 | 119163118 | - |
| 3UTR-intron | ENST00000270645 | ENST00000534838 | RCN3 | chr19 | 50046507 | + | PAPPA | chr9 | 119163118 | - |
| 3UTR-intron | ENST00000270645 | ENST00000483254 | RCN3 | chr19 | 50046507 | + | PAPPA | chr9 | 119163118 | - |
| intron-3UTR | ENST00000593644 | ENST00000328252 | RCN3 | chr19 | 50046507 | + | PAPPA | chr9 | 119163118 | - |
| intron-intron | ENST00000593644 | ENST00000534838 | RCN3 | chr19 | 50046507 | + | PAPPA | chr9 | 119163118 | - |
| intron-intron | ENST00000593644 | ENST00000483254 | RCN3 | chr19 | 50046507 | + | PAPPA | chr9 | 119163118 | - |
Top |
FusionProtFeatures for RCN3_PAPPA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RCN3 | PAPPA |