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Fusion gene ID: 30844 |
FusionGeneSummary for RC3H1_RC3H1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RC3H1_RC3H1 | Fusion gene ID: 30844 | Hgene | Tgene | Gene symbol | RC3H1 | RC3H1 | Gene ID | 149041 | 149041 |
| Gene name | ring finger and CCCH-type domains 1 | ring finger and CCCH-type domains 1 | |
| Synonyms | RNF198|ROQUIN | RNF198|ROQUIN | |
| Cytomap | 1q25.1 | 1q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | roquin-1RING finger and C3H zinc finger protein 1RING finger and CCCH-type zinc finger domain-containing protein 1RING finger protein 198probable E3 ubiquitin-protein ligase Roquin | roquin-1RING finger and C3H zinc finger protein 1RING finger and CCCH-type zinc finger domain-containing protein 1RING finger protein 198probable E3 ubiquitin-protein ligase Roquin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5TC82 | Q5TC82 | |
| Ensembl transtripts involved in fusion gene | ENST00000258349, ENST00000367696, ENST00000367694, | ENST00000258349, ENST00000367696, ENST00000367694, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RC3H1 [Title/Abstract] AND RC3H1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RC3H1 | GO:0000209 | protein polyubiquitination | 26489670 |
| Hgene | RC3H1 | GO:0000956 | nuclear-transcribed mRNA catabolic process | 25026078 |
| Tgene | RC3H1 | GO:0000209 | protein polyubiquitination | 26489670 |
| Tgene | RC3H1 | GO:0000956 | nuclear-transcribed mRNA catabolic process | 25026078 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DW438066 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000258349 | ENST00000258349 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000258349 | ENST00000367696 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000258349 | ENST00000367694 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000367696 | ENST00000258349 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000367696 | ENST00000367696 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000367696 | ENST00000367694 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000367694 | ENST00000258349 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000367694 | ENST00000367696 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
| intron-3UTR | ENST00000367694 | ENST00000367694 | RC3H1 | chr1 | 173907485 | - | RC3H1 | chr1 | 173907775 | - |
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FusionProtFeatures for RC3H1_RC3H1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RC3H1 | RC3H1 |