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Fusion gene ID: 30837 |
FusionGeneSummary for RBPMS_RBM26 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBPMS_RBM26 | Fusion gene ID: 30837 | Hgene | Tgene | Gene symbol | RBPMS | RBM26 | Gene ID | 11030 | 64062 |
| Gene name | RNA binding protein, mRNA processing factor | RNA binding motif protein 26 | |
| Synonyms | HERMES | ARRS2|C13orf10|PPP1R132|PRO1777|SE70-2|ZC3H17 | |
| Cytomap | 8p12 | 13q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein with multiple splicingRNA binding protein with multiple splicingheart and RRM expressed sequence | RNA-binding protein 26CTCL tumor antigen se70-2acidic rich RS domain containing 2cutaneous T-cell lymphoma tumor antigen se70-2protein phosphatase 1, regulatory 132 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q93062 | Q5T8P6 | |
| Ensembl transtripts involved in fusion gene | ENST00000538486, ENST00000397323, ENST00000320203, ENST00000287771, ENST00000339877, ENST00000517860, ENST00000520161, ENST00000519647, ENST00000520191, ENST00000520916, | ENST00000267229, ENST00000438737, ENST00000438724, ENST00000461008, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 4 X 4 X 1=16 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RBPMS [Title/Abstract] AND RBM26 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RBPMS | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 17099224 |
| Hgene | RBPMS | GO:0060391 | positive regulation of SMAD protein signal transduction | 17099224 |
| Tgene | RBM26 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF988612 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000538486 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000538486 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000538486 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000538486 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000397323 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000397323 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000397323 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000397323 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000320203 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000320203 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000320203 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000320203 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000287771 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000287771 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000287771 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000287771 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000339877 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000339877 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000339877 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000339877 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000517860 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000517860 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000517860 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000517860 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520161 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520161 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520161 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520161 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000519647 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000519647 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000519647 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000519647 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520191 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520191 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520191 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520191 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520916 | ENST00000267229 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520916 | ENST00000438737 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520916 | ENST00000438724 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
| intron-intron | ENST00000520916 | ENST00000461008 | RBPMS | chr8 | 30408153 | - | RBM26 | chr13 | 79929068 | - |
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FusionProtFeatures for RBPMS_RBM26 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBPMS | RBM26 |