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Fusion gene ID: 30812 |
FusionGeneSummary for RBMS3_LPCAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBMS3_LPCAT1 | Fusion gene ID: 30812 | Hgene | Tgene | Gene symbol | RBMS3 | LPCAT1 | Gene ID | 27303 | 79888 |
| Gene name | RNA binding motif single stranded interacting protein 3 | lysophosphatidylcholine acyltransferase 1 | |
| Synonyms | - | AGPAT10|AGPAT9|AYTL2|LPCAT-1|PFAAP3|lpcat|lysoPAFAT | |
| Cytomap | 3p24.1 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding motif, single-stranded-interacting protein 3RNA binding motif, single stranded interacting proteinRNA-binding protein | lysophosphatidylcholine acyltransferase 11-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPC acyltransferase 1acetyl-CoA:lyso-PAF acetyltransferaseacetyl-CoA:lyso-platelet-activating factor acetyltransfera | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6XE24 | Q8NF37 | |
| Ensembl transtripts involved in fusion gene | ENST00000434693, ENST00000396583, ENST00000383767, ENST00000445033, ENST00000273139, ENST00000383766, ENST00000452462, ENST00000456853, ENST00000473799, | ENST00000283415, ENST00000503252, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 5 X 5 X 3=75 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RBMS3 [Title/Abstract] AND LPCAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LPCAT1 | GO:0036151 | phosphatidylcholine acyl-chain remodeling | 21498505 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A1L2-01A | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000434693 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000434693 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| In-frame | ENST00000396583 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000396583 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| In-frame | ENST00000383767 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000383767 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| In-frame | ENST00000445033 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000445033 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| In-frame | ENST00000273139 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000273139 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| In-frame | ENST00000383766 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000383766 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| In-frame | ENST00000452462 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000452462 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| In-frame | ENST00000456853 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| 5CDS-intron | ENST00000456853 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| intron-3CDS | ENST00000473799 | ENST00000283415 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
| intron-intron | ENST00000473799 | ENST00000503252 | RBMS3 | chr3 | 29323247 | + | LPCAT1 | chr5 | 1501718 | - |
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FusionProtFeatures for RBMS3_LPCAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBMS3 | LPCAT1 |