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Fusion gene ID: 30783 |
FusionGeneSummary for RBM6_ARIH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBM6_ARIH2 | Fusion gene ID: 30783 | Hgene | Tgene | Gene symbol | RBM6 | ARIH2 | Gene ID | 10180 | 10425 |
| Gene name | RNA binding motif protein 6 | ariadne RBR E3 ubiquitin protein ligase 2 | |
| Synonyms | 3G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16 | ARI2|TRIAD1 | |
| Cytomap | 3p21.31 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein 6RNA-binding protein DEF-3lung cancer antigen NY-LU-12lung cancer protooncogene 11 | E3 ubiquitin-protein ligase ARIH2RING-type E3 ubiquitin transferase ARIH2all-trans retinoic acid inducible RING fingerariadne homolog 2protein ariadne-2 homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P78332 | O95376 | |
| Ensembl transtripts involved in fusion gene | ENST00000442092, ENST00000266022, ENST00000443081, ENST00000539992, ENST00000441115, ENST00000422955, ENST00000421682, | ENST00000356401, ENST00000449376, ENST00000490095, | |
| Fusion gene scores | * DoF score | 13 X 10 X 6=780 | 9 X 10 X 4=360 |
| # samples | 13 | 11 | |
| ** MAII score | log2(13/780*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RBM6 [Title/Abstract] AND ARIH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARIH2 | GO:0000209 | protein polyubiquitination | 16118314|19340006 |
| Tgene | ARIH2 | GO:0006511 | ubiquitin-dependent protein catabolic process | 16118314 |
| Tgene | ARIH2 | GO:0016567 | protein ubiquitination | 24076655 |
| Tgene | ARIH2 | GO:0048588 | developmental cell growth | 19340006 |
| Tgene | ARIH2 | GO:0070534 | protein K63-linked ubiquitination | 19340006 |
| Tgene | ARIH2 | GO:0070936 | protein K48-linked ubiquitination | 16118314|19340006 |
| Tgene | ARIH2 | GO:0071425 | hematopoietic stem cell proliferation | 16118314|19340006 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A1EO-01A | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000442092 | ENST00000356401 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000442092 | ENST00000449376 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 5CDS-3UTR | ENST00000442092 | ENST00000490095 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000266022 | ENST00000356401 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000266022 | ENST00000449376 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 5CDS-3UTR | ENST00000266022 | ENST00000490095 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000443081 | ENST00000356401 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000443081 | ENST00000449376 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 5CDS-3UTR | ENST00000443081 | ENST00000490095 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000539992 | ENST00000356401 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000539992 | ENST00000449376 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 5CDS-3UTR | ENST00000539992 | ENST00000490095 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 3UTR-3CDS | ENST00000441115 | ENST00000356401 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 3UTR-3CDS | ENST00000441115 | ENST00000449376 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 3UTR-3UTR | ENST00000441115 | ENST00000490095 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000422955 | ENST00000356401 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| In-frame | ENST00000422955 | ENST00000449376 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| 5CDS-3UTR | ENST00000422955 | ENST00000490095 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| intron-3CDS | ENST00000421682 | ENST00000356401 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| intron-3CDS | ENST00000421682 | ENST00000449376 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
| intron-3UTR | ENST00000421682 | ENST00000490095 | RBM6 | chr3 | 50099541 | + | ARIH2 | chr3 | 48999045 | + |
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FusionProtFeatures for RBM6_ARIH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBM6 | ARIH2 |