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Fusion gene ID: 30754 |
FusionGeneSummary for RBM39_WASF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBM39_WASF2 | Fusion gene ID: 30754 | Hgene | Tgene | Gene symbol | RBM39 | WASF2 | Gene ID | 9584 | 10163 |
| Gene name | RNA binding motif protein 39 | WAS protein family member 2 | |
| Synonyms | CAPER|CAPERalpha|FSAP59|HCC1|RNPC2 | IMD2|SCAR2|WASF4|WAVE2|dJ393P12.2 | |
| Cytomap | 20q11.22 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein 39CAPER alphaRNA-binding region (RNP1, RRM) containing 2coactivator of activating protein-1 and estrogen receptorsfunctional spliceosome-associated protein 59hepatocellular carcinoma protein 1splicing factor HCC1 | wiskott-Aldrich syndrome protein family member 2WASP family Verprolin-homologous protein 2WASP family protein member 2WASP family protein member 4protein WAVE-2putative Wiskott-Aldrich syndrome protein family member 4suppressor of cyclic-AMP recepto | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q14498 | Q9Y6W5 | |
| Ensembl transtripts involved in fusion gene | ENST00000253363, ENST00000361162, ENST00000528062, ENST00000407261, ENST00000397370, ENST00000463098, | ENST00000430629, ENST00000536657, | |
| Fusion gene scores | * DoF score | 13 X 11 X 8=1144 | 4 X 3 X 3=36 |
| # samples | 15 | 4 | |
| ** MAII score | log2(15/1144*10)=-2.93105264628251 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RBM39 [Title/Abstract] AND WASF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF762912 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000253363 | ENST00000430629 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000253363 | ENST00000536657 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000361162 | ENST00000430629 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000361162 | ENST00000536657 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000528062 | ENST00000430629 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000528062 | ENST00000536657 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000407261 | ENST00000430629 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000407261 | ENST00000536657 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000397370 | ENST00000430629 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000397370 | ENST00000536657 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000463098 | ENST00000430629 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
| intron-intron | ENST00000463098 | ENST00000536657 | RBM39 | chr20 | 34330111 | + | WASF2 | chr1 | 27752840 | - |
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FusionProtFeatures for RBM39_WASF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBM39 | WASF2 |