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Fusion gene ID: 30662 |
FusionGeneSummary for RBFOX2_MPPED1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RBFOX2_MPPED1 | Fusion gene ID: 30662 | Hgene | Tgene | Gene symbol | RBFOX2 | MPPED1 | Gene ID | 23543 | 758 |
| Gene name | RNA binding fox-1 homolog 2 | metallophosphoesterase domain containing 1 | |
| Synonyms | FOX2|Fox-2|HNRBP2|HRNBP2|RBM9|RTA|dJ106I20.3|fxh | 239AB|C22orf1|FAM1A | |
| Cytomap | 22q12.3 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activity | metallophosphoesterase domain-containing protein 1adult brain protein 239 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43251 | O15442 | |
| Ensembl transtripts involved in fusion gene | ENST00000405409, ENST00000414461, ENST00000449924, ENST00000262829, ENST00000397303, ENST00000359369, ENST00000416721, ENST00000438146, | ENST00000417669, ENST00000414469, ENST00000439548, ENST00000443721, ENST00000465861, ENST00000542779, ENST00000538182, | |
| Fusion gene scores | * DoF score | 13 X 8 X 8=832 | 2 X 2 X 2=8 |
| # samples | 14 | 2 | |
| ** MAII score | log2(14/832*10)=-2.57115670119613 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RBFOX2 [Title/Abstract] AND MPPED1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RBFOX2 | GO:0030520 | intracellular estrogen receptor signaling pathway | 11875103 |
| Hgene | RBFOX2 | GO:0045892 | negative regulation of transcription, DNA-templated | 11875103 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-S9-A7R7-01A | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000405409 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000405409 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000405409 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000405409 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000405409 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000405409 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000405409 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000414461 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000414461 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000414461 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000414461 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000414461 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000414461 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000414461 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000449924 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000449924 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000449924 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000449924 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000449924 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000449924 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000449924 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000262829 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000262829 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000262829 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000262829 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000262829 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000262829 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000262829 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000397303 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000397303 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000397303 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000397303 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000397303 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000397303 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000397303 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5UTR-3CDS | ENST00000359369 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5UTR-3CDS | ENST00000359369 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5UTR-5UTR | ENST00000359369 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5UTR-5UTR | ENST00000359369 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5UTR-intron | ENST00000359369 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5UTR-intron | ENST00000359369 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5UTR-intron | ENST00000359369 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000416721 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-3CDS | ENST00000416721 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000416721 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-5UTR | ENST00000416721 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000416721 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000416721 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| intron-intron | ENST00000416721 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| Frame-shift | ENST00000438146 | ENST00000417669 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| Frame-shift | ENST00000438146 | ENST00000414469 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5CDS-5UTR | ENST00000438146 | ENST00000439548 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5CDS-5UTR | ENST00000438146 | ENST00000443721 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5CDS-intron | ENST00000438146 | ENST00000465861 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5CDS-intron | ENST00000438146 | ENST00000542779 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
| 5CDS-intron | ENST00000438146 | ENST00000538182 | RBFOX2 | chr22 | 36334895 | - | MPPED1 | chr22 | 43870616 | + |
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FusionProtFeatures for RBFOX2_MPPED1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RBFOX2 | MPPED1 |