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Fusion gene ID: 30633

FusionGeneSummary for RBBP7_TTC24

Fusion gene summary

Fusion gene information	Fusion gene name: RBBP7_TTC24
	Fusion gene ID: 30633
		Hgene	Tgene
	Gene symbol	RBBP7	TTC24
	Gene ID	5931	164118
	Gene name	RB binding protein 7, chromatin remodeling factor	tetratricopeptide repeat domain 24
	Synonyms	RbAp46	-
	Cytomap	Xp22.2	1q22
	Type of gene	protein-coding	protein-coding
	Description	histone-binding protein RBBP7G1/S transition control protein-binding protein RbAp46RBBP-7histone acetyltransferase type B subunit 2nucleosome-remodeling factor subunit RBAP46retinoblastoma-binding protein 7retinoblastoma-binding protein RbAp46retin	tetratricopeptide repeat protein 24TPR repeat protein 24
	Modification date	20180522	20180402
	UniProtAcc	Q16576	A2A3L6
	Ensembl transtripts involved in fusion gene	ENST00000380087, ENST00000380084, ENST00000404022,	ENST00000368236, ENST00000368237, ENST00000478081,
Fusion gene scores	* DoF score	2 X 2 X 1=4	1 X 1 X 1=1
	# samples	2	1
	** MAII score	log2(2/4*10)=2.32192809488736	log2(1/1*10)=3.32192809488736
Context	PubMed: RBBP7 [Title/Abstract] AND TTC24 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RBBP7	GO:0030308	negative regulation of cell growth	9765217
Hgene	RBBP7	GO:0070370	cellular heat acclimation	7503932

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-DX-A1KY-01A	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000380087	ENST00000368236	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
Frame-shift	ENST00000380087	ENST00000368237	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
5CDS-intron	ENST00000380087	ENST00000478081	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
intron-3CDS	ENST00000380084	ENST00000368236	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
intron-3CDS	ENST00000380084	ENST00000368237	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
intron-intron	ENST00000380084	ENST00000478081	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
Frame-shift	ENST00000404022	ENST00000368236	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
Frame-shift	ENST00000404022	ENST00000368237	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+
5CDS-intron	ENST00000404022	ENST00000478081	RBBP7	chrX	16888161	-	TTC24	chr1	156552023	+

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FusionProtFeatures for RBBP7_TTC24

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RBBP7 Q16576	TTC24 A2A3L6

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Fusion gene ID: 30633

FusionGeneSummary for RBBP7_TTC24

FusionProtFeatures for RBBP7_TTC24