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Fusion gene ID: 3063 |
FusionGeneSummary for ASXL2_FKBP8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ASXL2_FKBP8 | Fusion gene ID: 3063 | Hgene | Tgene | Gene symbol | ASXL2 | FKBP8 | Gene ID | 55252 | 23770 |
| Gene name | ASXL transcriptional regulator 2 | FK506 binding protein 8 | |
| Synonyms | ASXH2|SHAPNS | FKBP38|FKBPr38 | |
| Cytomap | 2p23.3 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | putative Polycomb group protein ASXL2additional sex combs like 2, transcriptional regulatoradditional sex combs-like protein 2polycomb group protein ASXH2 | peptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFKBP-38FKBP-8PPIase FKBP8hFKBP38rotamase | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q76L83 | Q14318 | |
| Ensembl transtripts involved in fusion gene | ENST00000435504, ENST00000336112, ENST00000272341, ENST00000404843, ENST00000497092, | ENST00000597960, ENST00000610101, ENST00000596558, ENST00000222308, ENST00000608443, ENST00000453489, | |
| Fusion gene scores | * DoF score | 13 X 7 X 8=728 | 11 X 11 X 5=605 |
| # samples | 15 | 13 | |
| ** MAII score | log2(15/728*10)=-2.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/605*10)=-2.2184235191335 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ASXL2 [Title/Abstract] AND FKBP8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ASXL2 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway | 21047783 |
| Hgene | ASXL2 | GO:0045600 | positive regulation of fat cell differentiation | 21047783 |
| Hgene | ASXL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 21047783 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AR-A0U0-01A | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| TCGA | LD | BRCA | TCGA-AR-A0U0-01A | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000435504 | ENST00000597960 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000610101 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000596558 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000222308 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000608443 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000453489 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000336112 | ENST00000597960 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000336112 | ENST00000610101 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000336112 | ENST00000596558 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000336112 | ENST00000222308 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000336112 | ENST00000608443 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000336112 | ENST00000453489 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000272341 | ENST00000597960 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000272341 | ENST00000610101 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000272341 | ENST00000596558 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000272341 | ENST00000222308 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000272341 | ENST00000608443 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000272341 | ENST00000453489 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000404843 | ENST00000597960 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000404843 | ENST00000610101 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000404843 | ENST00000596558 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000404843 | ENST00000222308 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000404843 | ENST00000608443 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000404843 | ENST00000453489 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000497092 | ENST00000597960 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000497092 | ENST00000610101 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000497092 | ENST00000596558 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000497092 | ENST00000222308 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000497092 | ENST00000608443 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| intron-5UTR | ENST00000497092 | ENST00000453489 | ASXL2 | chr2 | 26058407 | - | FKBP8 | chr19 | 18652805 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000597960 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000610101 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000596558 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000222308 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000608443 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000435504 | ENST00000453489 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000336112 | ENST00000597960 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000336112 | ENST00000610101 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000336112 | ENST00000596558 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000336112 | ENST00000222308 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000336112 | ENST00000608443 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5CDS-5UTR | ENST00000336112 | ENST00000453489 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5UTR-5UTR | ENST00000272341 | ENST00000597960 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5UTR-5UTR | ENST00000272341 | ENST00000610101 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5UTR-5UTR | ENST00000272341 | ENST00000596558 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5UTR-5UTR | ENST00000272341 | ENST00000222308 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5UTR-5UTR | ENST00000272341 | ENST00000608443 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| 5UTR-5UTR | ENST00000272341 | ENST00000453489 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000404843 | ENST00000597960 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000404843 | ENST00000610101 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000404843 | ENST00000596558 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000404843 | ENST00000222308 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000404843 | ENST00000608443 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000404843 | ENST00000453489 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000497092 | ENST00000597960 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000497092 | ENST00000610101 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000497092 | ENST00000596558 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000497092 | ENST00000222308 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000497092 | ENST00000608443 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
| intron-5UTR | ENST00000497092 | ENST00000453489 | ASXL2 | chr2 | 26068350 | - | FKBP8 | chr19 | 18652808 | - |
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FusionProtFeatures for ASXL2_FKBP8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ASXL2 | FKBP8 |