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Fusion gene ID: 30586 |
FusionGeneSummary for RASSF8_RAD52 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RASSF8_RAD52 | Fusion gene ID: 30586 | Hgene | Tgene | Gene symbol | RASSF8 | RAD52 | Gene ID | 11228 | 5893 |
| Gene name | Ras association domain family member 8 | RAD52 homolog, DNA repair protein | |
| Synonyms | C12orf2|HOJ1 | - | |
| Cytomap | 12p12.1 | 12p13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras association domain-containing protein 8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8carcinoma-associated protein HOJ-1 | DNA repair protein RAD52 homologrecombination protein RAD52rhabdomyosarcoma antigen MU-RMS-40.23 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8NHQ8 | P43351 | |
| Ensembl transtripts involved in fusion gene | ENST00000381352, ENST00000405154, ENST00000542865, ENST00000541490, ENST00000282884, ENST00000538081, | ENST00000358495, ENST00000430095, ENST00000539046, ENST00000536177, ENST00000544742, ENST00000541619, ENST00000535376, ENST00000545564, | |
| Fusion gene scores | * DoF score | 8 X 4 X 7=224 | 3 X 5 X 4=60 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RASSF8 [Title/Abstract] AND RAD52 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RAD52 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing | 19506022 |
| Tgene | RAD52 | GO:0034599 | cellular response to oxidative stress | 19506022 |
| Tgene | RAD52 | GO:2000819 | regulation of nucleotide-excision repair | 19506022 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A2KD-01A | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000381352 | ENST00000358495 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000381352 | ENST00000430095 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000381352 | ENST00000539046 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000381352 | ENST00000536177 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000381352 | ENST00000544742 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000381352 | ENST00000541619 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000381352 | ENST00000535376 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000381352 | ENST00000545564 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000405154 | ENST00000358495 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000405154 | ENST00000430095 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000405154 | ENST00000539046 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000405154 | ENST00000536177 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000405154 | ENST00000544742 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000405154 | ENST00000541619 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000405154 | ENST00000535376 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000405154 | ENST00000545564 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000542865 | ENST00000358495 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000542865 | ENST00000430095 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000542865 | ENST00000539046 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000542865 | ENST00000536177 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000542865 | ENST00000544742 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000542865 | ENST00000541619 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000542865 | ENST00000535376 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000542865 | ENST00000545564 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000541490 | ENST00000358495 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000541490 | ENST00000430095 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000541490 | ENST00000539046 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-3CDS | ENST00000541490 | ENST00000536177 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000541490 | ENST00000544742 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000541490 | ENST00000541619 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000541490 | ENST00000535376 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 5UTR-intron | ENST00000541490 | ENST00000545564 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000282884 | ENST00000358495 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000282884 | ENST00000430095 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000282884 | ENST00000539046 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-3CDS | ENST00000282884 | ENST00000536177 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000282884 | ENST00000544742 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000282884 | ENST00000541619 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000282884 | ENST00000535376 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| intron-intron | ENST00000282884 | ENST00000545564 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-3CDS | ENST00000538081 | ENST00000358495 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-3CDS | ENST00000538081 | ENST00000430095 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-3CDS | ENST00000538081 | ENST00000539046 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-3CDS | ENST00000538081 | ENST00000536177 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-intron | ENST00000538081 | ENST00000544742 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-intron | ENST00000538081 | ENST00000541619 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-intron | ENST00000538081 | ENST00000535376 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
| 3UTR-intron | ENST00000538081 | ENST00000545564 | RASSF8 | chr12 | 26148063 | + | RAD52 | chr12 | 1036429 | - |
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FusionProtFeatures for RASSF8_RAD52 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RASSF8 | RAD52 |