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Fusion gene ID: 30572

FusionGeneSummary for RASSF4_DDB1

Fusion gene summary

Fusion gene information	Fusion gene name: RASSF4_DDB1
	Fusion gene ID: 30572
		Hgene	Tgene
	Gene symbol	RASSF4	DDB1
	Gene ID	83937	1642
	Gene name	Ras association domain family member 4	damage specific DNA binding protein 1
	Synonyms	AD037	DDBA\|UV-DDB1\|XAP1\|XPCE\|XPE\|XPE-BF
	Cytomap	10q11.21	11q12.2
	Type of gene	protein-coding	protein-coding
	Description	ras association domain-containing protein 4Ras association (RalGDS/AF-6) domain family 4Ras association (RalGDS/AF-6) domain family member 4Ras association domain family 4tumor suppressor RASSF4	DNA damage-binding protein 1DDB p127 subunitDNA damage-binding protein aHBV X-associated protein 1UV-DDB 1UV-damaged DNA-binding factorUV-damaged DNA-binding protein 1XAP-1XPE-binding factordamage-specific DNA binding protein 1, 127kDaxeroderma
	Modification date	20180519	20180523
	UniProtAcc	Q9H2L5	Q16531
	Ensembl transtripts involved in fusion gene	ENST00000334940, ENST00000374417, ENST00000340258, ENST00000472561,	ENST00000301764, ENST00000450997, ENST00000451943, ENST00000538470, ENST00000545930,
Fusion gene scores	* DoF score	5 X 5 X 1=25	4 X 4 X 2=32
	# samples	5	5
	** MAII score	log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RASSF4 [Title/Abstract] AND DDB1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DDB1	GO:0006511	ubiquitin-dependent protein catabolic process	11673459
Tgene	DDB1	GO:0035518	histone H2A monoubiquitination	22334663
Tgene	DDB1	GO:0051702	interaction with symbiont	23137809
Tgene	DDB1	GO:0070914	UV-damage excision repair	22334663

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA738370	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000334940	ENST00000301764	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000334940	ENST00000450997	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000334940	ENST00000451943	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000334940	ENST00000538470	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000334940	ENST00000545930	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000374417	ENST00000301764	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000374417	ENST00000450997	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000374417	ENST00000451943	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000374417	ENST00000538470	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000374417	ENST00000545930	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000340258	ENST00000301764	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000340258	ENST00000450997	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000340258	ENST00000451943	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000340258	ENST00000538470	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000340258	ENST00000545930	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000472561	ENST00000301764	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000472561	ENST00000450997	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-3UTR	ENST00000472561	ENST00000451943	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000472561	ENST00000538470	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+
intron-intron	ENST00000472561	ENST00000545930	RASSF4	chr10	45472005	+	DDB1	chr11	61067373	+

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FusionProtFeatures for RASSF4_DDB1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RASSF4 Q9H2L5	DDB1 Q16531

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Fusion gene ID: 30572

FusionGeneSummary for RASSF4_DDB1

FusionProtFeatures for RASSF4_DDB1