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Fusion gene ID: 30443 |
FusionGeneSummary for RAPGEF5_MRPS22 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAPGEF5_MRPS22 | Fusion gene ID: 30443 | Hgene | Tgene | Gene symbol | RAPGEF5 | MRPS22 | Gene ID | 9771 | 56945 |
| Gene name | Rap guanine nucleotide exchange factor 5 | mitochondrial ribosomal protein S22 | |
| Synonyms | GFR|MR-GEF|REPAC | C3orf5|COXPD5|GIBT|GK002|MRP-S22|RPMS22 | |
| Cytomap | 7p15.3 | 3q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac | 28S ribosomal protein S22, mitochondrialS22mtmitochondrial small ribosomal subunit protein mS22 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q92565 | P82650 | |
| Ensembl transtripts involved in fusion gene | ENST00000344041, ENST00000475788, ENST00000405243, ENST00000401957, | ENST00000495075, ENST00000310776, ENST00000465056, ENST00000478464, ENST00000489521, | |
| Fusion gene scores | * DoF score | 11 X 11 X 6=726 | 4 X 4 X 2=32 |
| # samples | 11 | 4 | |
| ** MAII score | log2(11/726*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RAPGEF5 [Title/Abstract] AND MRPS22 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-46-6025-01A | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000344041 | ENST00000495075 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| Frame-shift | ENST00000344041 | ENST00000310776 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| Frame-shift | ENST00000344041 | ENST00000465056 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| Frame-shift | ENST00000344041 | ENST00000478464 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| 5CDS-intron | ENST00000344041 | ENST00000489521 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| 5UTR-3CDS | ENST00000475788 | ENST00000495075 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| 5UTR-3CDS | ENST00000475788 | ENST00000310776 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| 5UTR-3CDS | ENST00000475788 | ENST00000465056 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| 5UTR-3CDS | ENST00000475788 | ENST00000478464 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| 5UTR-intron | ENST00000475788 | ENST00000489521 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| Frame-shift | ENST00000405243 | ENST00000495075 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| Frame-shift | ENST00000405243 | ENST00000310776 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| Frame-shift | ENST00000405243 | ENST00000465056 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| Frame-shift | ENST00000405243 | ENST00000478464 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| 5CDS-intron | ENST00000405243 | ENST00000489521 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| intron-3CDS | ENST00000401957 | ENST00000495075 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| intron-3CDS | ENST00000401957 | ENST00000310776 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| intron-3CDS | ENST00000401957 | ENST00000465056 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| intron-3CDS | ENST00000401957 | ENST00000478464 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
| intron-intron | ENST00000401957 | ENST00000489521 | RAPGEF5 | chr7 | 22270465 | - | MRPS22 | chr3 | 139065720 | + |
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FusionProtFeatures for RAPGEF5_MRPS22 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAPGEF5 | MRPS22 |