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Fusion gene ID: 30404 |
FusionGeneSummary for RAP1GDS1_RAP1GDS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAP1GDS1_RAP1GDS1 | Fusion gene ID: 30404 | Hgene | Tgene | Gene symbol | RAP1GDS1 | RAP1GDS1 | Gene ID | 5910 | 5910 |
| Gene name | Rap1 GTPase-GDP dissociation stimulator 1 | Rap1 GTPase-GDP dissociation stimulator 1 | |
| Synonyms | GDS1|SmgGDS | GDS1|SmgGDS | |
| Cytomap | 4q23 | 4q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rap1 GTPase-GDP dissociation stimulator 1RAP1, GTP-GDP dissociation stimulator 1SMG GDS proteinSMG P21 stimulatory GDP/GTP exchange proteinexchange factor smgGDS | rap1 GTPase-GDP dissociation stimulator 1RAP1, GTP-GDP dissociation stimulator 1SMG GDS proteinSMG P21 stimulatory GDP/GTP exchange proteinexchange factor smgGDS | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P52306 | P52306 | |
| Ensembl transtripts involved in fusion gene | ENST00000380158, ENST00000264572, ENST00000408927, ENST00000512857, ENST00000453712, ENST00000339360, ENST00000408900, | ENST00000380158, ENST00000264572, ENST00000408927, ENST00000512857, ENST00000453712, ENST00000339360, ENST00000408900, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 3 X 5 X 1=15 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RAP1GDS1 [Title/Abstract] AND RAP1GDS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB857283 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000380158 | ENST00000380158 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000380158 | ENST00000264572 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000380158 | ENST00000408927 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000380158 | ENST00000512857 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000380158 | ENST00000453712 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000380158 | ENST00000339360 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000380158 | ENST00000408900 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000264572 | ENST00000380158 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000264572 | ENST00000264572 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000264572 | ENST00000408927 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000264572 | ENST00000512857 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000264572 | ENST00000453712 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000264572 | ENST00000339360 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000264572 | ENST00000408900 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| 3UTR-3UTR | ENST00000408927 | ENST00000380158 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| 3UTR-intron | ENST00000408927 | ENST00000264572 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| 3UTR-3UTR | ENST00000408927 | ENST00000408927 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| 3UTR-intron | ENST00000408927 | ENST00000512857 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| 3UTR-3UTR | ENST00000408927 | ENST00000453712 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| 3UTR-3UTR | ENST00000408927 | ENST00000339360 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| 3UTR-3UTR | ENST00000408927 | ENST00000408900 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000512857 | ENST00000380158 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000512857 | ENST00000264572 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000512857 | ENST00000408927 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000512857 | ENST00000512857 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000512857 | ENST00000453712 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000512857 | ENST00000339360 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000512857 | ENST00000408900 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000453712 | ENST00000380158 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000453712 | ENST00000264572 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000453712 | ENST00000408927 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000453712 | ENST00000512857 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000453712 | ENST00000453712 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000453712 | ENST00000339360 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000453712 | ENST00000408900 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000339360 | ENST00000380158 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000339360 | ENST00000264572 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000339360 | ENST00000408927 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000339360 | ENST00000512857 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000339360 | ENST00000453712 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000339360 | ENST00000339360 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000339360 | ENST00000408900 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000408900 | ENST00000380158 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000408900 | ENST00000264572 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000408900 | ENST00000408927 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-intron | ENST00000408900 | ENST00000512857 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000408900 | ENST00000453712 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000408900 | ENST00000339360 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
| intron-3UTR | ENST00000408900 | ENST00000408900 | RAP1GDS1 | chr4 | 99364242 | + | RAP1GDS1 | chr4 | 99363300 | + |
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FusionProtFeatures for RAP1GDS1_RAP1GDS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAP1GDS1 | RAP1GDS1 |