	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 30389

FusionGeneSummary for RAP1B_TUBGCP3

Fusion gene summary

Fusion gene information	Fusion gene name: RAP1B_TUBGCP3
	Fusion gene ID: 30389
		Hgene	Tgene
	Gene symbol	RAP1B	TUBGCP3
	Gene ID	5908	10426
	Gene name	RAP1B, member of RAS oncogene family	tubulin gamma complex associated protein 3
	Synonyms	K-REV\|RAL1B	104p\|ALP6\|GCP3\|Grip104\|SPBC98\|Spc98\|Spc98p
	Cytomap	12q15	13q34
	Type of gene	protein-coding	protein-coding
	Description	ras-related protein Rap-1bGTP-binding protein smg p21BRAS-related protein RAP1BRas family small GTP binding protein RAP1Bsmall GTP binding protein	gamma-tubulin complex component 3gamma-ring complex protein 104 kDaspindle pole body protein Spc98 homolog
	Modification date	20180527	20180523
	UniProtAcc	P61224	Q96CW5
	Ensembl transtripts involved in fusion gene	ENST00000250559, ENST00000393436, ENST00000341355, ENST00000537460, ENST00000463493, ENST00000450214, ENST00000543393, ENST00000378985, ENST00000540209, ENST00000539091, ENST00000542145, ENST00000543697, ENST00000541216,	ENST00000261965, ENST00000375669, ENST00000462580,
Fusion gene scores	* DoF score	12 X 6 X 7=504	4 X 4 X 2=32
	# samples	11	5
	** MAII score	log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RAP1B [Title/Abstract] AND TUBGCP3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAP1B	GO:0071320	cellular response to cAMP	21840392

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF327763	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000250559	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000250559	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000250559	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000393436	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000393436	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000393436	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000341355	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000341355	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000341355	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000537460	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000537460	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000537460	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000463493	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000463493	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000463493	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000450214	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000450214	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000450214	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000543393	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000543393	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000543393	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000378985	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000378985	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000378985	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000540209	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000540209	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000540209	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000539091	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000539091	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000539091	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000542145	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000542145	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000542145	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000543697	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000543697	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000543697	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000541216	ENST00000261965	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000541216	ENST00000375669	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+
intron-intron	ENST00000541216	ENST00000462580	RAP1B	chr12	69032201	+	TUBGCP3	chr13	113193332	+

Top

FusionProtFeatures for RAP1B_TUBGCP3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAP1B P61224	TUBGCP3 Q96CW5

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 30389

FusionGeneSummary for RAP1B_TUBGCP3

FusionProtFeatures for RAP1B_TUBGCP3