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Fusion gene ID: 30360 |
FusionGeneSummary for RANGAP1_FNTA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RANGAP1_FNTA | Fusion gene ID: 30360 | Hgene | Tgene | Gene symbol | RANGAP1 | FNTA | Gene ID | 5905 | 2339 |
| Gene name | Ran GTPase activating protein 1 | farnesyltransferase, CAAX box, alpha | |
| Synonyms | Fug1|RANGAP|SD | FPTA|PGGT1A|PTAR2 | |
| Cytomap | 22q13.2 | 8p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ran GTPase-activating protein 1segregation distorter homologsegregation distortion | protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaFTase-alphaGGTase-I-alphafarnesyl-protein transferase alpha-subunitprotein prenyltransferase alpha subunit repeat containing 2ras proteins prenyltransferase subunit alphatype | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P46060 | P49354 | |
| Ensembl transtripts involved in fusion gene | ENST00000405486, ENST00000356244, ENST00000455915, ENST00000407260, | ENST00000302279, ENST00000342116, ENST00000524546, ENST00000529687, | |
| Fusion gene scores | * DoF score | 12 X 10 X 6=720 | 4 X 7 X 4=112 |
| # samples | 12 | 8 | |
| ** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RANGAP1 [Title/Abstract] AND FNTA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RANGAP1 | GO:0046826 | negative regulation of protein export from nucleus | 16449645 |
| Hgene | RANGAP1 | GO:0090630 | activation of GTPase activity | 16428860 |
| Tgene | FNTA | GO:0018343 | protein farnesylation | 16893176|19228685 |
| Tgene | FNTA | GO:0018344 | protein geranylgeranylation | 16893176 |
| Tgene | FNTA | GO:0090044 | positive regulation of tubulin deacetylation | 19228685 |
| Tgene | FNTA | GO:0090045 | positive regulation of deacetylase activity | 19228685 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-34-5239-01A | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000405486 | ENST00000302279 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-intron | ENST00000405486 | ENST00000342116 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-3UTR | ENST00000405486 | ENST00000524546 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-5UTR | ENST00000405486 | ENST00000529687 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-3CDS | ENST00000356244 | ENST00000302279 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-intron | ENST00000356244 | ENST00000342116 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-3UTR | ENST00000356244 | ENST00000524546 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-5UTR | ENST00000356244 | ENST00000529687 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-3CDS | ENST00000455915 | ENST00000302279 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-intron | ENST00000455915 | ENST00000342116 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-3UTR | ENST00000455915 | ENST00000524546 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-5UTR | ENST00000455915 | ENST00000529687 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-3CDS | ENST00000407260 | ENST00000302279 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-intron | ENST00000407260 | ENST00000342116 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-3UTR | ENST00000407260 | ENST00000524546 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
| intron-5UTR | ENST00000407260 | ENST00000529687 | RANGAP1 | chr22 | 41681367 | - | FNTA | chr8 | 42914235 | + |
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FusionProtFeatures for RANGAP1_FNTA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RANGAP1 | FNTA |