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Fusion gene ID: 30180

FusionGeneSummary for RAD51B_RAD51B

Fusion gene summary

Fusion gene information	Fusion gene name: RAD51B_RAD51B
	Fusion gene ID: 30180
		Hgene	Tgene
	Gene symbol	RAD51B	RAD51B
	Gene ID	5890	5890
	Gene name	RAD51 paralog B	RAD51 paralog B
	Synonyms	R51H2\|RAD51L1\|REC2	R51H2\|RAD51L1\|REC2
	Cytomap	14q24.1	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20180523	20180523
	UniProtAcc	O15315	O15315
	Ensembl transtripts involved in fusion gene	ENST00000487861, ENST00000471583, ENST00000487270, ENST00000488612, ENST00000390683, ENST00000469165,	ENST00000487861, ENST00000471583, ENST00000487270, ENST00000488612, ENST00000390683, ENST00000469165,
Fusion gene scores	* DoF score	13 X 9 X 7=819	25 X 15 X 8=3000
	# samples	15	33
	** MAII score	log2(15/819*10)=-2.44890095114513 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(33/3000*10)=-3.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAD51B [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AL040421	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
ChiTaRS3.1			CV375773	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000487861	ENST00000487861	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487861	ENST00000471583	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487861	ENST00000487270	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487861	ENST00000488612	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487861	ENST00000390683	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487861	ENST00000469165	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000471583	ENST00000487861	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000471583	ENST00000471583	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000471583	ENST00000487270	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000471583	ENST00000488612	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000471583	ENST00000390683	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000471583	ENST00000469165	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487270	ENST00000487861	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487270	ENST00000471583	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487270	ENST00000487270	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487270	ENST00000488612	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487270	ENST00000390683	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487270	ENST00000469165	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000488612	ENST00000487861	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000488612	ENST00000471583	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000488612	ENST00000487270	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000488612	ENST00000488612	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000488612	ENST00000390683	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000488612	ENST00000469165	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000390683	ENST00000487861	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000390683	ENST00000471583	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000390683	ENST00000487270	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000390683	ENST00000488612	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000390683	ENST00000390683	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000390683	ENST00000469165	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000469165	ENST00000487861	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000469165	ENST00000471583	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000469165	ENST00000487270	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000469165	ENST00000488612	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000469165	ENST00000390683	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000469165	ENST00000469165	RAD51B	chr14	68358891	-	RAD51B	chr14	68358983	+
intron-intron	ENST00000487861	ENST00000487861	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487861	ENST00000471583	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487861	ENST00000487270	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487861	ENST00000488612	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487861	ENST00000390683	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487861	ENST00000469165	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000471583	ENST00000487861	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000471583	ENST00000471583	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000471583	ENST00000487270	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000471583	ENST00000488612	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000471583	ENST00000390683	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000471583	ENST00000469165	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487270	ENST00000487861	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487270	ENST00000471583	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487270	ENST00000487270	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487270	ENST00000488612	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487270	ENST00000390683	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000487270	ENST00000469165	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000488612	ENST00000487861	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000488612	ENST00000471583	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000488612	ENST00000487270	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000488612	ENST00000488612	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000488612	ENST00000390683	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000488612	ENST00000469165	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000390683	ENST00000487861	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000390683	ENST00000471583	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000390683	ENST00000487270	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000390683	ENST00000488612	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000390683	ENST00000390683	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000390683	ENST00000469165	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000469165	ENST00000487861	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000469165	ENST00000471583	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000469165	ENST00000487270	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000469165	ENST00000488612	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000469165	ENST00000390683	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+
intron-intron	ENST00000469165	ENST00000469165	RAD51B	chr14	69075881	-	RAD51B	chr14	69075010	+

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FusionProtFeatures for RAD51B_RAD51B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAD51B O15315	RAD51B O15315

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Fusion gene ID: 30180

FusionGeneSummary for RAD51B_RAD51B

FusionProtFeatures for RAD51B_RAD51B