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Fusion gene ID: 30164 |
FusionGeneSummary for RAD23B_GSN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD23B_GSN | Fusion gene ID: 30164 | Hgene | Tgene | Gene symbol | RAD23B | GSN | Gene ID | 5887 | 2934 |
| Gene name | RAD23 homolog B, nucleotide excision repair protein | gelsolin | |
| Synonyms | HHR23B|HR23B|P58 | ADF|AGEL | |
| Cytomap | 9q31.2 | 9q33.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UV excision repair protein RAD23 homolog BRAD23, yeast homolog of, BXP-C repair complementing complex 58 kDaXP-C repair complementing proteinXP-C repair-complementing complex 58 kDa protein | gelsolinactin-depolymerizing factorbrevin | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P54727 | P06396 | |
| Ensembl transtripts involved in fusion gene | ENST00000358015, ENST00000416373, | ENST00000373823, ENST00000373808, ENST00000436847, ENST00000449733, ENST00000412819, ENST00000394353, ENST00000341272, ENST00000545652, ENST00000373818, ENST00000485767, ENST00000373807, ENST00000373806, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 8 X 1=40 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(9/40*10)=1.16992500144231 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RAD23B [Title/Abstract] AND GSN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAD23B | GO:0000715 | nucleotide-excision repair, DNA damage recognition | 19941824 |
| Hgene | RAD23B | GO:0006289 | nucleotide-excision repair | 8168482|9734359 |
| Hgene | RAD23B | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 19435460 |
| Tgene | GSN | GO:0030041 | actin filament polymerization | 3020431 |
| Tgene | GSN | GO:0051014 | actin filament severing | 3020431 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF755677 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000358015 | ENST00000373823 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000373808 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000436847 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000449733 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000412819 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000394353 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000341272 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000545652 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000373818 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000485767 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000373807 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000358015 | ENST00000373806 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000373823 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000373808 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000436847 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000449733 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000412819 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000394353 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000341272 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000545652 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000373818 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000485767 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000373807 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
| intron-intron | ENST00000416373 | ENST00000373806 | RAD23B | chr9 | 110062421 | - | GSN | chr9 | 124080776 | - |
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FusionProtFeatures for RAD23B_GSN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD23B | GSN |