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Fusion gene ID: 30160 |
FusionGeneSummary for RAD21_ZC4H2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD21_ZC4H2 | Fusion gene ID: 30160 | Hgene | Tgene | Gene symbol | RAD21 | ZC4H2 | Gene ID | 5885 | 55906 |
| Gene name | RAD21 cohesin complex component | zinc finger C4H2-type containing | |
| Synonyms | CDLS4|HR21|HRAD21|MCD1|NXP1|SCC1|hHR21 | HCA127|KIAA1166|WRWF|WWS | |
| Cytomap | 8q24.11 | Xq11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | double-strand-break repair protein rad21 homologNXP-1RAD21 homologSCC1 homologkleisinnuclear matrix protein 1protein involved in DNA double-strand break repairsister chromatid cohesion 1 | zinc finger C4H2 domain-containing proteinhepatocellular carcinoma-associated antigen 127zinc finger, C4H2 domain containing | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O60216 | Q9NQZ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000297338, ENST00000523986, ENST00000517749, ENST00000518055, ENST00000523547, | ENST00000337990, ENST00000545618, ENST00000447788, ENST00000374839, ENST00000488608, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RAD21 [Title/Abstract] AND ZC4H2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAD21 | GO:0006357 | regulation of transcription by RNA polymerase II | 19468298 |
| Tgene | ZC4H2 | GO:0007399 | nervous system development | 23623388 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CX788771 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000297338 | ENST00000337990 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000297338 | ENST00000545618 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000297338 | ENST00000447788 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000297338 | ENST00000374839 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-5UTR | ENST00000297338 | ENST00000488608 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523986 | ENST00000337990 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523986 | ENST00000545618 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523986 | ENST00000447788 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523986 | ENST00000374839 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-5UTR | ENST00000523986 | ENST00000488608 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000517749 | ENST00000337990 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000517749 | ENST00000545618 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000517749 | ENST00000447788 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000517749 | ENST00000374839 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-5UTR | ENST00000517749 | ENST00000488608 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000518055 | ENST00000337990 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000518055 | ENST00000545618 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000518055 | ENST00000447788 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000518055 | ENST00000374839 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-5UTR | ENST00000518055 | ENST00000488608 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523547 | ENST00000337990 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523547 | ENST00000545618 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523547 | ENST00000447788 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-3UTR | ENST00000523547 | ENST00000374839 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
| intron-5UTR | ENST00000523547 | ENST00000488608 | RAD21 | chr8 | 117870608 | - | ZC4H2 | chrX | 64137256 | - |
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FusionProtFeatures for RAD21_ZC4H2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD21 | ZC4H2 |