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Fusion gene ID: 30159 |
FusionGeneSummary for RAD21_TPM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD21_TPM2 | Fusion gene ID: 30159 | Hgene | Tgene | Gene symbol | RAD21 | TPM2 | Gene ID | 5885 | 7169 |
| Gene name | RAD21 cohesin complex component | tropomyosin 2 | |
| Synonyms | CDLS4|HR21|HRAD21|MCD1|NXP1|SCC1|hHR21 | AMCD1|DA1|DA2B|HEL-S-273|NEM4|TMSB | |
| Cytomap | 8q24.11 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | double-strand-break repair protein rad21 homologNXP-1RAD21 homologSCC1 homologkleisinnuclear matrix protein 1protein involved in DNA double-strand break repairsister chromatid cohesion 1 | tropomyosin beta chainepididymis secretory protein Li 273nemaline myopathy type 4tropomyosin 2 (beta) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O60216 | P07951 | |
| Ensembl transtripts involved in fusion gene | ENST00000297338, ENST00000523986, ENST00000517749, ENST00000518055, ENST00000523547, | ENST00000378300, ENST00000378292, ENST00000329305, ENST00000360958, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 8 X 2=128 |
| # samples | 4 | 10 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/128*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAD21 [Title/Abstract] AND TPM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAD21 | GO:0006357 | regulation of transcription by RNA polymerase II | 19468298 |
| Tgene | TPM2 | GO:0043462 | regulation of ATPase activity | 17194691 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-KD-A5QU-01A | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000297338 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| In-frame | ENST00000297338 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| In-frame | ENST00000297338 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| In-frame | ENST00000297338 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000523986 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000517749 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| Frame-shift | ENST00000518055 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000378300 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000378292 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000329305 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
| intron-3CDS | ENST00000523547 | ENST00000360958 | RAD21 | chr8 | 117862857 | - | TPM2 | chr9 | 35685548 | - |
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FusionProtFeatures for RAD21_TPM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD21 | TPM2 |