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Fusion gene ID: 30151 |
FusionGeneSummary for RAD17_CNTN5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD17_CNTN5 | Fusion gene ID: 30151 | Hgene | Tgene | Gene symbol | RAD17 | CNTN5 | Gene ID | 5884 | 53942 |
| Gene name | RAD17 checkpoint clamp loader component | contactin 5 | |
| Synonyms | CCYC|HRAD17|R24L|RAD17SP|RAD24 | HNB-2s|NB-2 | |
| Cytomap | 5q13.2 | 11q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17) | contactin-5neural adhesion moleculeneural recognition molecule NB-2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O75943 | O94779 | |
| Ensembl transtripts involved in fusion gene | ENST00000361732, ENST00000509734, ENST00000354868, ENST00000521422, ENST00000504177, ENST00000354312, ENST00000345306, ENST00000305138, ENST00000282891, ENST00000358030, ENST00000380774, | ENST00000527185, ENST00000528682, ENST00000524871, ENST00000418526, ENST00000279463, ENST00000524560, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 16 X 11 X 12=2112 |
| # samples | 3 | 16 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(16/2112*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAD17 [Title/Abstract] AND CNTN5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-TM-A84I-01A | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000361732 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000361732 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000361732 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000361732 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000361732 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000361732 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000509734 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000509734 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000509734 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000509734 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000509734 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000509734 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354868 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354868 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354868 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354868 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354868 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000354868 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000521422 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000521422 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000521422 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000521422 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000521422 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000521422 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| intron-intron | ENST00000504177 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| intron-intron | ENST00000504177 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| intron-intron | ENST00000504177 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| intron-intron | ENST00000504177 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| intron-intron | ENST00000504177 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| intron-3UTR | ENST00000504177 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354312 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354312 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354312 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354312 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000354312 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000354312 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000345306 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000345306 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000345306 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000345306 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000345306 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000345306 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000305138 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000305138 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000305138 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000305138 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000305138 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000305138 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000282891 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000282891 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000282891 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000282891 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000282891 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000282891 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000358030 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000358030 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000358030 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000358030 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000358030 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000358030 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000380774 | ENST00000527185 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000380774 | ENST00000528682 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000380774 | ENST00000524871 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000380774 | ENST00000418526 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-intron | ENST00000380774 | ENST00000279463 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
| 5CDS-3UTR | ENST00000380774 | ENST00000524560 | RAD17 | chr5 | 68677884 | + | CNTN5 | chr11 | 100226848 | + |
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FusionProtFeatures for RAD17_CNTN5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD17 | CNTN5 |