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Fusion gene ID: 30095 |
FusionGeneSummary for RABEP1_CDRT8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RABEP1_CDRT8 | Fusion gene ID: 30095 | Hgene | Tgene | Gene symbol | RABEP1 | CDRT8 | Gene ID | 9135 | 94151 |
| Gene name | rabaptin, RAB GTPase binding effector protein 1 | CMT1A duplicated region transcript 8 | |
| Synonyms | RAB5EP|RABPT5 | - | |
| Cytomap | 17p13.2 | 17p12 | |
| Type of gene | protein-coding | ncRNA | |
| Description | rab GTPase-binding effector protein 1neurocrescinrabaptin-4rabaptin-5rabaptin-5alpharenal carcinoma antigen NY-REN-17 | - | |
| Modification date | 20180522 | 20180329 | |
| UniProtAcc | Q15276 | ||
| Ensembl transtripts involved in fusion gene | ENST00000408982, ENST00000262477, ENST00000537505, ENST00000546142, ENST00000341923, ENST00000570487, | ENST00000579752, | |
| Fusion gene scores | * DoF score | 11 X 8 X 7=616 | 1 X 1 X 1=1 |
| # samples | 17 | 1 | |
| ** MAII score | log2(17/616*10)=-1.8573956045572 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RABEP1 [Title/Abstract] AND CDRT8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-LL-A5YN-01A | RABEP1 | chr17 | 5212117 | + | CDRT8 | chr17 | 15008860 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000408982 | ENST00000579752 | RABEP1 | chr17 | 5212117 | + | CDRT8 | chr17 | 15008860 | - |
| 5CDS-5UTR | ENST00000262477 | ENST00000579752 | RABEP1 | chr17 | 5212117 | + | CDRT8 | chr17 | 15008860 | - |
| intron-5UTR | ENST00000537505 | ENST00000579752 | RABEP1 | chr17 | 5212117 | + | CDRT8 | chr17 | 15008860 | - |
| 5CDS-5UTR | ENST00000546142 | ENST00000579752 | RABEP1 | chr17 | 5212117 | + | CDRT8 | chr17 | 15008860 | - |
| 5CDS-5UTR | ENST00000341923 | ENST00000579752 | RABEP1 | chr17 | 5212117 | + | CDRT8 | chr17 | 15008860 | - |
| intron-5UTR | ENST00000570487 | ENST00000579752 | RABEP1 | chr17 | 5212117 | + | CDRT8 | chr17 | 15008860 | - |
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FusionProtFeatures for RABEP1_CDRT8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RABEP1 | CDRT8 |