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Fusion gene ID: 3009 |
FusionGeneSummary for ASNA1_PAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ASNA1_PAF1 | Fusion gene ID: 3009 | Hgene | Tgene | Gene symbol | ASNA1 | PAF1 | Gene ID | 439 | 54623 |
| Gene name | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) | PAF1 homolog, Paf1/RNA polymerase II complex component | |
| Synonyms | ARSA-I|ARSA1|ASNA-I|GET3|TRC40 | F23149_1|PD2 | |
| Cytomap | 19p13.13 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATPase ASNA1golgi to ER traffic 3 homologtransmembrane domain recognition complex 40 kDa ATPase subunit | RNA polymerase II-associated factor 1 homologPaf1, RNA polymerase II associated factor, homologpancreatic differentiation protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43681 | Q8N7H5 | |
| Ensembl transtripts involved in fusion gene | ENST00000591090, ENST00000357332, | ENST00000221265, ENST00000595564, ENST00000221266, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ASNA1 [Title/Abstract] AND PAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PAF1 | GO:0010390 | histone monoubiquitination | 16307923 |
| Tgene | PAF1 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 20178742 |
| Tgene | PAF1 | GO:0033523 | histone H2B ubiquitination | 16307923 |
| Tgene | PAF1 | GO:0045638 | negative regulation of myeloid cell differentiation | 20541477 |
| Tgene | PAF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20178742 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA236423 | ASNA1 | chr19 | 12859073 | - | PAF1 | chr19 | 39880146 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000591090 | ENST00000221265 | ASNA1 | chr19 | 12859073 | - | PAF1 | chr19 | 39880146 | + |
| 3UTR-3CDS | ENST00000591090 | ENST00000595564 | ASNA1 | chr19 | 12859073 | - | PAF1 | chr19 | 39880146 | + |
| 3UTR-3CDS | ENST00000591090 | ENST00000221266 | ASNA1 | chr19 | 12859073 | - | PAF1 | chr19 | 39880146 | + |
| 3UTR-3CDS | ENST00000357332 | ENST00000221265 | ASNA1 | chr19 | 12859073 | - | PAF1 | chr19 | 39880146 | + |
| 3UTR-3CDS | ENST00000357332 | ENST00000595564 | ASNA1 | chr19 | 12859073 | - | PAF1 | chr19 | 39880146 | + |
| 3UTR-3CDS | ENST00000357332 | ENST00000221266 | ASNA1 | chr19 | 12859073 | - | PAF1 | chr19 | 39880146 | + |
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FusionProtFeatures for ASNA1_PAF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ASNA1 | PAF1 |