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Fusion gene ID: 30016 |
FusionGeneSummary for RAB3IP_ERBB3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB3IP_ERBB3 | Fusion gene ID: 30016 | Hgene | Tgene | Gene symbol | RAB3IP | ERBB3 | Gene ID | 117177 | 2065 |
| Gene name | RAB3A interacting protein | erb-b2 receptor tyrosine kinase 3 | |
| Synonyms | RABIN3|RABIN8 | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | |
| Cytomap | 12q15 | 12q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rab-3A-interacting proteinSSX2 interacting proteinrab3A-interacting proteinrabin-3 | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q96QF0 | P21860 | |
| Ensembl transtripts involved in fusion gene | ENST00000247833, ENST00000378815, ENST00000325555, ENST00000483530, ENST00000550536, ENST00000362025, ENST00000551641, ENST00000553099, ENST00000550847, | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | |
| Fusion gene scores | * DoF score | 15 X 7 X 9=945 | 25 X 8 X 14=2800 |
| # samples | 17 | 25 | |
| ** MAII score | log2(17/945*10)=-2.47477958297073 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/2800*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAB3IP [Title/Abstract] AND ERBB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAB3IP | GO:0006612 | protein targeting to membrane | 23382462 |
| Tgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
| Tgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
| Tgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
| Tgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Tgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
| Tgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-5856-01A | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000247833 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000247833 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-5UTR | ENST00000247833 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000247833 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000247833 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000247833 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| Frame-shift | ENST00000378815 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000378815 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-5UTR | ENST00000378815 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000378815 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000378815 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000378815 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5UTR-3CDS | ENST00000325555 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5UTR-intron | ENST00000325555 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5UTR-5UTR | ENST00000325555 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5UTR-intron | ENST00000325555 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5UTR-intron | ENST00000325555 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5UTR-intron | ENST00000325555 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| Frame-shift | ENST00000483530 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000483530 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-5UTR | ENST00000483530 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000483530 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000483530 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000483530 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| Frame-shift | ENST00000550536 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000550536 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-5UTR | ENST00000550536 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000550536 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000550536 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000550536 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| Frame-shift | ENST00000362025 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000362025 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-5UTR | ENST00000362025 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000362025 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000362025 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| 5CDS-intron | ENST00000362025 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-3CDS | ENST00000551641 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000551641 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-5UTR | ENST00000551641 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000551641 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000551641 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000551641 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-3CDS | ENST00000553099 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000553099 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-5UTR | ENST00000553099 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000553099 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000553099 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000553099 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-3CDS | ENST00000550847 | ENST00000267101 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000550847 | ENST00000450146 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-5UTR | ENST00000550847 | ENST00000415288 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000550847 | ENST00000553131 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000550847 | ENST00000411731 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
| intron-intron | ENST00000550847 | ENST00000549832 | RAB3IP | chr12 | 70150443 | + | ERBB3 | chr12 | 56477535 | + |
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FusionProtFeatures for RAB3IP_ERBB3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB3IP | ERBB3 |