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Fusion gene ID: 300 |
FusionGeneSummary for ABTB2_NDUFB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABTB2_NDUFB1 | Fusion gene ID: 300 | Hgene | Tgene | Gene symbol | ABTB2 | NDUFB1 | Gene ID | 25841 | 4707 |
| Gene name | ankyrin repeat and BTB domain containing 2 | NADH:ubiquinone oxidoreductase subunit B1 | |
| Synonyms | ABTB2A|BTBD22 | CI-MNLL|CI-SGDH|MNLL | |
| Cytomap | 11p13 | 14q32.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat and BTB/POZ domain-containing protein 2ankyrin repeat and BTB (POZ) domain containing 2 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDaNADH-ubiquinone oxidoreductase MNLL subunitcomplex I MNLL subunitcomplex I-MNLL | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q8N961 | O75438 | |
| Ensembl transtripts involved in fusion gene | ENST00000298992, ENST00000435224, ENST00000530814, | ENST00000553514, ENST00000329559, ENST00000605997, ENST00000555441, ENST00000556555, | |
| Fusion gene scores | * DoF score | 6 X 4 X 3=72 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ABTB2 [Title/Abstract] AND NDUFB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0XU-01A | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000298992 | ENST00000553514 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000298992 | ENST00000329559 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| In-frame | ENST00000298992 | ENST00000605997 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000298992 | ENST00000555441 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| 5CDS-intron | ENST00000298992 | ENST00000556555 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| In-frame | ENST00000435224 | ENST00000553514 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000435224 | ENST00000329559 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| In-frame | ENST00000435224 | ENST00000605997 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| Frame-shift | ENST00000435224 | ENST00000555441 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| 5CDS-intron | ENST00000435224 | ENST00000556555 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000553514 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000329559 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000605997 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-3CDS | ENST00000530814 | ENST00000555441 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
| intron-intron | ENST00000530814 | ENST00000556555 | ABTB2 | chr11 | 34378248 | - | NDUFB1 | chr14 | 92582573 | - |
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FusionProtFeatures for ABTB2_NDUFB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABTB2 | NDUFB1 |