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Fusion gene ID: 29975

FusionGeneSummary for RAB33B_NAA15

Fusion gene summary

Fusion gene information	Fusion gene name: RAB33B_NAA15
	Fusion gene ID: 29975
		Hgene	Tgene
	Gene symbol	RAB33B	NAA15
	Gene ID	83452	80155
	Gene name	RAB33B, member RAS oncogene family	N(alpha)-acetyltransferase 15, NatA auxiliary subunit
	Synonyms	SMC2	Ga19\|MRD50\|NARG1\|NAT1P\|NATH\|TBDN\|TBDN100
	Cytomap	4q31.1	4q31.1
	Type of gene	protein-coding	protein-coding
	Description	ras-related protein Rab-33B	N-alpha-acetyltransferase 15, NatA auxiliary subunitN-terminal acetyltransferaseNMDA receptor regulated 1NMDA receptor-regulated protein 1gastric cancer antigen Ga19protein tubedown-1transcriptional coactivator tubedown-100tubedown-1
	Modification date	20180523	20180523
	UniProtAcc	Q9H082	Q9BXJ9
	Ensembl transtripts involved in fusion gene	ENST00000305626, ENST00000507271,	ENST00000296543, ENST00000398947, ENST00000480277, ENST00000515576,
Fusion gene scores	* DoF score	3 X 2 X 3=18	7 X 5 X 7=245
	# samples	3	7
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAB33B [Title/Abstract] AND NAA15 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NAA15	GO:0006474	N-terminal protein amino acid acetylation	15496142
Tgene	NAA15	GO:0045893	positive regulation of transcription, DNA-templated	12145306

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UCS	TCGA-N8-A4PL-01A	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000305626	ENST00000296543	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+
In-frame	ENST00000305626	ENST00000398947	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+
5CDS-intron	ENST00000305626	ENST00000480277	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+
5CDS-intron	ENST00000305626	ENST00000515576	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+
intron-3CDS	ENST00000507271	ENST00000296543	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+
intron-3CDS	ENST00000507271	ENST00000398947	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+
intron-intron	ENST00000507271	ENST00000480277	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+
intron-intron	ENST00000507271	ENST00000515576	RAB33B	chr4	140375598	+	NAA15	chr4	140255328	+

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FusionProtFeatures for RAB33B_NAA15

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAB33B Q9H082	NAA15 Q9BXJ9

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Fusion gene ID: 29975

FusionGeneSummary for RAB33B_NAA15

FusionProtFeatures for RAB33B_NAA15