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Fusion gene ID: 29932 |
FusionGeneSummary for RAB21_KSR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB21_KSR1 | Fusion gene ID: 29932 | Hgene | Tgene | Gene symbol | RAB21 | KSR1 | Gene ID | 23011 | 8844 |
| Gene name | RAB21, member RAS oncogene family | kinase suppressor of ras 1 | |
| Synonyms | - | KSR|RSU2 | |
| Cytomap | 12q21.1 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-related protein Rab-21GTP-binding protein RAB21 | kinase suppressor of Ras 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UL25 | Q8IVT5 | |
| Ensembl transtripts involved in fusion gene | ENST00000261263, | ENST00000509603, ENST00000319524, ENST00000268763, ENST00000398988, ENST00000581975, ENST00000582410, ENST00000578981, | |
| Fusion gene scores | * DoF score | 8 X 4 X 2=64 | 10 X 7 X 5=350 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/350*10)=-1.95935801550265 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAB21 [Title/Abstract] AND KSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAB21 | GO:0017157 | regulation of exocytosis | 22705394 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A09Q-01A | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261263 | ENST00000509603 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| In-frame | ENST00000261263 | ENST00000319524 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-5UTR | ENST00000261263 | ENST00000268763 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-5UTR | ENST00000261263 | ENST00000398988 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-intron | ENST00000261263 | ENST00000581975 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-intron | ENST00000261263 | ENST00000582410 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-intron | ENST00000261263 | ENST00000578981 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
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FusionProtFeatures for RAB21_KSR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB21 | KSR1 |